Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. - Wikidata - awgldk - TriplyDB

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.

http://www.wikidata.org/entity/Q33697376

about

A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis Cutting the brakes on hematopoietic regeneration by blocking TGFβ to limit chemotherapy-induced myelosuppression The Evi5 family in cellular physiology and pathology Runx family genes in a cartilaginous fish, the elephant shark (Callorhinchus milii).A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients.Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum).High fat diet rapidly suppresses B lymphopoiesis by disrupting the supportive capacity of the bone marrow niche.Runx1 loss minimally impacts long-term hematopoietic stem cells RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndrome Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells B-lineage transcription factors and cooperating gene lesions required for leukemia development.A role for RUNX1 in hematopoiesis and myeloid leukemia.Posttranslational modifications of RUNX1 as potential anticancer targets.The RUNX family: developmental regulators in cancer.Mouse models for core binding factor leukemia.The RUNX complex: reaching beyond haematopoiesis into immunity.RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response.Runx Family Genes in Tissue Stem Cell Dynamics.Roles of the RUNX1 Enhancer in Normal Hematopoiesis and Leukemogenesis.Cell-based analysis of structure-function activity of threonine aspartase 1 Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells.RUNX1 cooperates with FLT3-ITD to induce leukemia.Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.Loss of RUNX1 function results in enhanced granulocyte-colony-stimulating factor-mediated mobilization.RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia.Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development.A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells.Emerging molecular predictive and prognostic factors in acute myeloid leukemia.

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Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.

http://www.wikidata.org/entity/Q33697376

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Stem cell exhaustion due to Ru ...... activation in leukemogenesis.

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Stem cell exhaustion due to Ru ...... activation in leukemogenesis.

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type

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Stem cell exhaustion due to Ru ...... activation in leukemogenesis.

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Stem cell exhaustion due to Ru ...... activation in leukemogenesis.

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prefLabel

Stem cell exhaustion due to Ru ...... activation in leukemogenesis.

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Stem cell exhaustion due to Ru ...... activation in leukemogenesis.

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Stem cell exhaustion due to Ru ...... activation in leukemogenesis.

@en

P2093

Bindya Jacob

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Chelsia Qiuxia Wang

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Dan R Littman

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Ichiro Taniuchi

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Motomi Osato

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Namiko Yamashita

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Norio Asou

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Yoshiaki Ito

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P2860

The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1

Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

Inducible gene targeting in mice

Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.

AML1 deletion in adult mice causes splenomegaly and lymphomas.

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1610-1620

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10.1182/BLOOD-2009-07-232249

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20008790

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2830765

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