Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease. - Wikidata - awgldk - TriplyDB

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease.

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease.

http://www.wikidata.org/entity/Q45091101

about

Disturbed copper bioavailability in Alzheimer's disease Copper promotes the trafficking of the amyloid precursor protein Cerebral bioimaging of Cu, Fe, Zn, and Mn in the MPTP mouse model of Parkinson's disease using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).Multifunctional antioxidants for the treatment of age-related diseases "Pulling the plug" on cellular copper: the role of mitochondria in copper export.Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells.Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD Copper binding to the Alzheimer's disease amyloid precursor protein Challenges associated with metal chelation therapy in Alzheimer's disease Intake of copper has no effect on cognition in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial.Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders.Gene expression patterns in the progression of canine copper-associated chronic hepatitis.Clawing back: broadening the notion of metal chelators in medicine Pharmacotherapeutic targets in Alzheimer's disease Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease.Copper in Alzheimer's disease: too much or too little?Novel drug targets based on metallobiology of Alzheimer's disease.Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders.Functions of Aβ, sAPPα and sAPPβ : similarities and differences.Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease.Pichia pastoris: protein production host and model organism for biomedical research.Biometals and their therapeutic implications in Alzheimer's disease.Metals in Alzheimer's and Parkinson's Disease: Relevance to Dementia with Lewy Bodies.Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments.Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.Nicotianamine forms complexes with Zn(II) in vivo.BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.Copper and Alzheimer's Disease.Serum Iron, Zinc, and Copper Levels in Patients with Alzheimer's Disease: A Replication Study and Meta-Analyses.Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2.Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.Copper is required for prion protein-associated superoxide dismutase-I activity in Pichia pastoris.The role of copper ions in pathophysiology and fluorescent sensors for the detection thereof.Molecular determinants of Alzheimer’s disease Aβ peptide neurotoxicity Role of amyloid-β–metal interactions in Alzheimer’s disease

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P2860

Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease.

http://www.wikidata.org/entity/Q45091101

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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name

Clioquinol mediates copper upt ...... rotein of Alzheimer's disease.

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Clioquinol mediates copper upt ...... rotein of Alzheimer's disease.

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type

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Clioquinol mediates copper upt ...... rotein of Alzheimer's disease.

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Clioquinol mediates copper upt ...... rotein of Alzheimer's disease.

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Clioquinol mediates copper upt ...... rotein of Alzheimer's disease.

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Clioquinol mediates copper upt ...... rotein of Alzheimer's disease.

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P2093

Andreas Simons

http://www.w3.org/2001/XMLSchema#string

Carina Treiber

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Markus Strauss

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Mathias Hafner

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Thomas A Bayer

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P2860

Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

Evidence for a copper-binding superfamily of the amyloid precursor protein

Elemental imbalances in the olfactory pathway in Alzheimer's disease

Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice

In vivo reduction of amyloid-beta by a mutant copper transporter

Pipes and wiring: the regulation of copper uptake and distribution in yeast.

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Alzheimer's disease