Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats.
about
Most efficient cocaine hydrolase designed by virtual screening of transition statesStructural analysis of thermostabilizing mutations of cocaine esteraseGene transfer of mutant mouse cholinesterase provides high lifetime expression and reduced cocaine responses with no evident toxicityDesign of high-activity mutants of human butyrylcholinesterase against (-)-cocaine: structural and energetic factors affecting the catalytic efficiency.Physiologic and metabolic safety of butyrylcholinesterase gene therapy in miceStructure-and-mechanism-based design and discovery of therapeutics for cocaine overdose and addiction.Rational design of an enzyme mutant for anti-cocaine therapeuticsComputational redesign of human butyrylcholinesterase for anticocaine medication.Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicityCombined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion.Identification of human butyrylcholinesterase organophosphate-resistant variants through a novel mammalian enzyme functional screen.Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector-Delivered Cocaine Hydrolase.An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic propertiesProspects, promise and problems on the road to effective vaccines and related therapies for substance abuseInterception of cocaine by enzyme or antibody delivered with viral gene transfer: a novel strategy for preventing relapse in recovering drug users.Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approachFree-energy perturbation simulation on transition states and redesign of butyrylcholinesterase.Recent progress in protein drug design and discovery with a focus on novel approaches to the development of anti-cocaine medications.Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: evidence for enzymatic activity.A highly efficient cocaine-detoxifying enzyme obtained by computational design.Cocaine hydrolase gene therapy for cocaine abuseCharacterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaine.Computational design of a human butyrylcholinesterase mutant for accelerating cocaine hydrolysis based on the transition-state simulation.Kinetic characterization of a cocaine hydrolase engineered from mouse butyrylcholinesterase.Reaction mechanism for cocaine esterase-catalyzed hydrolyses of (+)- and (-)-cocaine: unexpected common rate-determining step.The concept of pharmacologic cocaine interception as a treatment for drug abuse.Pharmacokinetic approaches to treatment of drug addiction.
P2860
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P2860
Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
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2004年學術文章
@zh-hant
name
Gene transfer of cocaine hydro ...... responses to cocaine in rats.
@en
Gene transfer of cocaine hydro ...... responses to cocaine in rats.
@nl
type
label
Gene transfer of cocaine hydro ...... responses to cocaine in rats.
@en
Gene transfer of cocaine hydro ...... responses to cocaine in rats.
@nl
prefLabel
Gene transfer of cocaine hydro ...... responses to cocaine in rats.
@en
Gene transfer of cocaine hydro ...... responses to cocaine in rats.
@nl
P2093
P356
P1476
Gene transfer of cocaine hydro ...... responses to cocaine in rats.
@en
P2093
Elena Atanasova
James D Pancook
Jeffry D Watkins
Stephen Brimijoin
P304
P356
10.1124/MOL.104.006924
P577
2004-10-01T00:00:00Z