Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells.
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Discovery of cellular regulation by protein degradationK-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genesThe dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure.Organization and genesis of dihydrofolate reductase amplicons in the genome of a methotrexate-resistant Chinese hamster ovary cell line.Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell linesThe gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.Analysis of gene amplification in human tumor cell lines.Multidrug resistance in oncology: diagnostic and therapeutic approaches.A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.Cloning by gene amplification of two loci conferring multiple drug resistance in SaccharomycesLeukemia relapse reconsidered from the molecular aspect.Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells.Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistanceExpression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastineDNA topoisomerase II as a target for cancer chemotherapy.Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell lineFunctional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures.Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane.Expression of P-glycoprotein mRNA in human gastric tumors.Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cellsGenetics of multidrug resistance.Amplification units containing human N-myc and c-myc genesIsolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cellsExpression of MDR1/P glycoprotein in human sarcomas.Cytogenetic and cellular characteristics of a human embryonal rhabdomyosarcoma cell line, RMS-YMFifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneityP-glycoprotein expression in locally advanced breast cancer treated by neoadjuvant chemotherapyDerivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells.mdm2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line.Marine medaka ATP-binding cassette (ABC) superfamily and new insight into teleost Abch nomenclature.Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis.Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.DNA amplification in multidrug, cross-resistant Chinese hamster ovary cells: molecular characterization and cytogenetic localization of the amplified DNAP-glycoprotein structure and evolutionary homologies.The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research.Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line.The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.Changes in intra- or extracellular pH do not mediate P-glycoprotein-dependent multidrug resistance.Structure and expression of the human MDR (P-glycoprotein) gene family.
P2860
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P2860
Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells.
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh-hant
name
Amplification of specific DNA ...... ance in Chinese hamster cells.
@en
Amplification of specific DNA ...... ance in Chinese hamster cells.
@nl
type
label
Amplification of specific DNA ...... ance in Chinese hamster cells.
@en
Amplification of specific DNA ...... ance in Chinese hamster cells.
@nl
prefLabel
Amplification of specific DNA ...... ance in Chinese hamster cells.
@en
Amplification of specific DNA ...... ance in Chinese hamster cells.
@nl
P2093
P2860
P356
P1433
P1476
Amplification of specific DNA ...... ance in Chinese hamster cells.
@en
P2093
Abelson HT
Housman DE
Roninson IB
Varshavsky A
P2860
P2888
P304
P356
10.1038/309626A0
P407
P577
1984-06-01T00:00:00Z
P6179
1021717165