Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease.
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The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's DiseasePhosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical ImplicationsTranscriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasisEfficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis)Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicityReview: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibitionInhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's diseaseStriatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes.Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitorPatented PDE10A inhibitors: novel compounds since 2007.A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.Phosphodiesterase 10A inhibitors: analysis of US/EP patents granted since 2012.Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.Radiosynthesis and biological evaluation of the new PDE10A radioligand [18 F]AQ28A.Early or late-stage anti-N-terminal Huntingtin intrabody gene therapy reduces pathological features in B6.HDR6/1 mice.Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Disease.Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases.Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry.
P2860
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P2860
Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Phosphodiesterase 10 inhibitio ...... model of Huntington's disease.
@en
Phosphodiesterase 10 inhibitio ...... model of Huntington's disease.
@nl
type
label
Phosphodiesterase 10 inhibitio ...... model of Huntington's disease.
@en
Phosphodiesterase 10 inhibitio ...... model of Huntington's disease.
@nl
prefLabel
Phosphodiesterase 10 inhibitio ...... model of Huntington's disease.
@en
Phosphodiesterase 10 inhibitio ...... model of Huntington's disease.
@nl
P2093
P1476
Phosphodiesterase 10 inhibitio ...... model of Huntington's disease.
@en
P2093
Carmela Giampà
Daunia Laurenti
Fabrizia Marullo
Francesca R Fusco
Giorgio Bernardi
Stefano Patassini
P304
P356
10.1016/J.NBD.2009.02.014
P577
2009-03-09T00:00:00Z