Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. - Wikidata - awgldk - TriplyDB

Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization.

Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization.

http://www.wikidata.org/entity/Q45345753

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Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease Cullin-RING ubiquitin ligases: global regulation and activation cycles SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1 FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.Proximity-induced activation of human Cdc34 through heterologous dimerization.Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation Control of cell growth by the SCF and APC/C ubiquitin ligases Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p Conservation of the COP9/signalosome in budding yeast Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels.Cullin-RING ligases in regulation of autophagy Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases Regulation of abiotic stress signal transduction by E3 ubiquitin ligases in Arabidopsis.Crystal structure of the human COP9 signalosome VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathways The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34 DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1 Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2 Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo.AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response.Ubiquitin, hormones and biotic stress in plants Nedd8 on cullin: building an expressway to protein destruction.

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P2860

Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization.

http://www.wikidata.org/entity/Q45345753

description

2000 nî lūn-bûn

@nan

2000年の論文

@ja

2000年学术文章

@wuu

2000年学术文章

@zh

2000年学术文章

@zh-cn

2000年学术文章

@zh-hans

2000年学术文章

@zh-my

2000年学术文章

@zh-sg

2000年學術文章

@yue

2000年學術文章

@zh-hant

name

Conjugation of Nedd8 to CUL1 e ...... mote ubiquitin polymerization.

@en

Conjugation of Nedd8 to CUL1 e ...... mote ubiquitin polymerization.

@nl

type

label

Conjugation of Nedd8 to CUL1 e ...... mote ubiquitin polymerization.

@en

Conjugation of Nedd8 to CUL1 e ...... mote ubiquitin polymerization.

@nl

prefLabel

Conjugation of Nedd8 to CUL1 e ...... mote ubiquitin polymerization.

@en

Conjugation of Nedd8 to CUL1 e ...... mote ubiquitin polymerization.

@nl

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P2860

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P1433

Journal of Biological Chemistry

P1476

Conjugation of Nedd8 to CUL1 e ...... mote ubiquitin polymerization.

@en

P2093

A Chen

http://www.w3.org/2001/XMLSchema#string

K Wu

http://www.w3.org/2001/XMLSchema#string

Z Q Pan

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes

The ubiquitin system

P304

32317-32324

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P31

scholarly article

P356

10.1074/JBC.M004847200

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P407

P433

41

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P478

275

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P577

2000-10-01T00:00:00Z

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P698

10921923

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