Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG
about
Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depressionAllosteric modulation of metabotropic glutamate receptors.Role of the Transforming-Growth-Factor-β1 Gene in Late-Onset Alzheimer's Disease: Implications for the TreatmentThe metabotropic glutamate 2/3 receptor antagonist LY341495 differentially affects recognition memory in rats.SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways.Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1.Combining two repurposed drugs as a promising approach for Alzheimer's disease therapyOpioid system and Alzheimer's disease.Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brainTargeting glutamate receptors to tackle the pathogenesis, clinical symptoms and levodopa-induced dyskinesia associated with Parkinson's disease.Therapeutic potential of targeting glutamate receptors in Parkinson's disease.Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indicationsGenome-wide association study of language performance in Alzheimer's disease.Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP, Long-Term Potentiation, and Disrupts Memory Reconsolidation.mGluR2 versus mGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic mGluR3 Strengthen Working Memory Networks.Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs.Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord.Emerging Roles of TWIK-1 Heterodimerization in the Brain.Group II Metabotropic Glutamate Receptors: Role in Pain Mechanisms and Pain Modulation
P2860
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P2860
Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG
description
2010 nî lūn-bûn
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2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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2010年學術文章
@zh-hant
name
Targeting group II metabotropi ...... whereas dual activation of mG
@en
Targeting group II metabotropi ...... whereas dual activation of mG
@nl
type
label
Targeting group II metabotropi ...... whereas dual activation of mG
@en
Targeting group II metabotropi ...... whereas dual activation of mG
@nl
prefLabel
Targeting group II metabotropi ...... whereas dual activation of mG
@en
Targeting group II metabotropi ...... whereas dual activation of mG
@nl
P2093
P50
P356
P1476
Targeting group II metabotropi ...... 3 receptors is neuroprotective
@en
P2093
Agata Copani
Barbara Riozzi
Beverly A Heinz
Eric S Nisenbaum
Filippo Caraci
Gemma Molinaro
Thomas C Britton
Xushan Wang
P304
P356
10.1124/MOL.110.067488
P50
P577
2010-12-15T00:00:00Z