Firefly luciferase mutants as sensors of proteome stress. - Wikidata - awgldk - TriplyDB

Firefly luciferase mutants as sensors of proteome stress.

Firefly luciferase mutants as sensors of proteome stress.

http://www.wikidata.org/entity/Q45362617

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Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodies Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes Longitudinal measures of proteostasis in live neurons: features that determine fate in models of neurodegenerative disease Approaches to engineer stability of beetle luciferases Huntington's disease: underlying molecular mechanisms and emerging concepts Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans Modulation of the maladaptive stress response to manage diseases of protein folding Rapid flow cytometric measurement of protein inclusions and nuclear trafficking.Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae.Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitin-dependent degradation of misfolded cytosolic proteins.Conformational analysis of misfolded protein aggregation by FRET and live-cell imaging techniques Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1 Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress.Protein misfolding specifies recruitment to cytoplasmic inclusion bodies Data interpretation: deciphering the biological function of Type 2 diabetes associated risk loci.Using Caenorhabditis elegans as a model system to study protein homeostasis in a multicellular organism.Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.Widespread Proteome Remodeling and Aggregation in Aging C. elegans.Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.Light-dependent and circadian transcription dynamics in vivo recorded with a destabilized luciferase reporter in Neurospora Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition.A cellular system that degrades misfolded proteins and protects against neurodegeneration Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease.Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.Targeting protein aggregation for the treatment of degenerative diseases Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells.Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease.Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.Differentiated cytoplasmic granule formation in quiescent and non-quiescent cells upon chronological aging Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.Conserved C-terminal nascent peptide binding domain of HYPK facilitates its chaperone-like activity.Cytosolic proteostasis through importing of misfolded proteins into mitochondria.HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells.Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance.When proteostasis goes bad: Protein aggregation in the cell.The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.A thiol probe for measuring unfolded protein load and proteostasis in cells.Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis.

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P2860

Firefly luciferase mutants as sensors of proteome stress.

http://www.wikidata.org/entity/Q45362617

description

2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

@zh-my

2011年学术文章

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2011年學術文章

@yue

2011年學術文章

@zh-hant

name

Firefly luciferase mutants as sensors of proteome stress.

@en

Firefly luciferase mutants as sensors of proteome stress.

@nl

type

label

Firefly luciferase mutants as sensors of proteome stress.

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Firefly luciferase mutants as sensors of proteome stress.

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prefLabel

Firefly luciferase mutants as sensors of proteome stress.

@en

Firefly luciferase mutants as sensors of proteome stress.

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Firefly luciferase mutants as sensors of proteome stress.

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Adriana Villella

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Andreas Bracher

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Christian Loew

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Dan Garza

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Min Zheng

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Prasad Kasturi

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Swasti Raychaudhuri

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879-884

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scholarly article

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10.1038/NMETH.1697

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10

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8

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Franz-Ulrich Hartl

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2011-09-04T00:00:00Z

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51618537

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