Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
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Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccinationThe growth threshold conjecture: a theoretical framework for understanding T-cell toleranceEpitope-specific TCR repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptidesProtective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation ThresholdIdentification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profilingPC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection.The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.Connections: can the 20th century coronary heart disease epidemic reveal something about the 1918 influenza lethality?Diverse heterologous primary infections radically alter immunodominance hierarchies and clinical outcomes following H7N9 influenza challenge in miceImmunity to seasonal and pandemic influenza A virusesAnti-IFN-γ and peptide-tolerization therapies inhibit acute lung injury induced by cross-reactive influenza A-specific memory T cellsDetection of site-specific positive Darwinian selection on pandemic influenza A/H1N1 virus genome: integrative approaches.Physiological numbers of CD4+ T cells generate weak recall responses following influenza virus challengeAltered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansionResponses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope.Armed response: how dying cells influence T-cell functions.Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominanceERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responsesMHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell responseAge-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice.Role of T-cell epitope-based vaccine in prophylactic and therapeutic applications.Induction of memory cytotoxic T cells to influenza A virus and subsequent viral clearance is not modulated by PB1-F2-dependent inflammasome activation.A multi-valent vaccine approach that elicits broad immunity within an influenza subtype.Mixed proteasomes function to increase viral peptide diversity and broaden antiviral CD8+ T cell responsesCD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance.Human immunodeficiency virus type 1 Gag p24 alters the composition of immunoproteasomes and affects antigen presentation.A theory of immunodominance and adaptive regulation.MHC class I antigen presentation and implications for developing a new generation of therapeutic vaccines.Shaping the T-cell repertoire in the periphery.T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.Mucosal polyinosinic-polycytidylic acid improves protection elicited by replicating influenza vaccines via enhanced dendritic cell function and T cell immunity.Thinking About Broadly Cross-Reactive Vaccines
P2860
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P2860
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
@en
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
@nl
type
label
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
@en
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
@nl
prefLabel
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
@en
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
@nl
P2093
P50
P1476
Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses.
@en
P2093
Melissa Y Morris
Rachael Keating
Scott A Brown
P304
P356
10.4049/JIMMUNOL.178.5.3091
P407
P577
2007-03-01T00:00:00Z