Comprehensive genomic access to vector integration in clinical gene therapy. - Wikidata - awgldk - TriplyDB

Comprehensive genomic access to vector integration in clinical gene therapy.

Comprehensive genomic access to vector integration in clinical gene therapy.

http://www.wikidata.org/entity/Q45855528

about

Retroviral integrations in gene therapy trials Bioinformatics and HIV latency.Development of Hematopoietic Stem Cell Based Gene Therapy for HIV-1 Infection: Considerations for Proof of Concept Studies and Translation to Standard Medical Practice Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?Gene therapy from the perspective of systems biology.Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles.Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites.Comparing DNA integration site clusters with scan statistics.Cytoreductive conditioning intensity predicts clonal diversity in ADA-SCID retroviral gene therapy patients.Vector integration and tumorigenesis.CRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient Cells Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts.Analyzing the number of common integration sites of viral vectors--new methods and computer programs.Estimating abundances of retroviral insertion sites from DNA fragment length data.Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence.High-throughput, sensitive quantification of repopulating hematopoietic stem cell clones.Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors.Linear amplification mediated PCR--localization of genetic elements and characterization of unknown flanking DNA.Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease.Identifying viral integration sites using SeqMap 2.0.Assessing the potential for AAV vector genotoxicity in a murine model.Lentiviral vector integration profiles differ in rodent postmitotic tissues A combinatorial approach to the restriction of a mouse genome.Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk A method to sequence and quantify DNA integration for monitoring outcome in gene therapy.Contributions of gene marking to cell and gene therapies.Fanconi anemia gene editing by the CRISPR/Cas9 system.Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.Quantitative shearing linear amplification polymerase chain reaction: an improved method for quantifying lentiviral vector insertion sites in transplanted hematopoietic cell systems Improving the efficiency of transposon mutagenesis in Salmonella enteritidis by overcoming host-restriction barriers.No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells.Retroviral vectors: post entry events and genomic alterations.Applications of next-generation sequencing technologies to diagnostic virology.Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies.Presence of a trs-Like Motif Promotes Rep-Mediated Wild-Type Adeno-Associated Virus Type 2 Integration.Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo.

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Comprehensive genomic access to vector integration in clinical gene therapy.

http://www.wikidata.org/entity/Q45855528

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2009年學術文章

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name

Comprehensive genomic access to vector integration in clinical gene therapy.

@en

Comprehensive genomic access to vector integration in clinical gene therapy.

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type

label

Comprehensive genomic access to vector integration in clinical gene therapy.

@en

Comprehensive genomic access to vector integration in clinical gene therapy.

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prefLabel

Comprehensive genomic access to vector integration in clinical gene therapy.

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Comprehensive genomic access to vector integration in clinical gene therapy.

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Nature Medicine

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Comprehensive genomic access to vector integration in clinical gene therapy.

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Ali Nowrouzi

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Anna Paruzynski

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Anne Arens

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Annette Deichmann

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Cynthia C Bartholomae

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H Bobby Gaspar

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Hanno Glimm

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Kamaljit S Balaggan

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Katrin Faber

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Kerstin Schwarzwaelder

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10.1038/NM.2057

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Christof von Kalle

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Alessandra Recchia

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Claudia Cattoglio

Adrian J Thrasher

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2009-11-22T00:00:00Z

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