CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. - Wikidata - awgldk - TriplyDB

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

http://www.wikidata.org/entity/Q45907066

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Islet inflammation: a unifying target for diabetes treatment?Transcriptional regulation of chemokine genes: a link to pancreatic islet inflammation?Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice TLR4 and Insulin Resistance.Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1.COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways Transcription of the gene encoding TNF-α is increased by IL-1β in rat and human islets and β-cell lines Adipose tissue remodeling as homeostatic inflammation.Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice.Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle Induction of an inflammatory loop by interleukin-1β and tumor necrosis factor-α involves NF-kB and STAT-1 in differentiated human neuroprogenitor cells.Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization.Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice.Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease.CCL20 is elevated during obesity and differentially regulated by NF-κB subunits in pancreatic β-cells.Expression and regulation of chemokines in murine and human type 1 diabetes.Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes.Effect of CXCL10 receptor antagonist on islet cell apoptosis in a type I diabetes rat model.Back From the Brink: The Uses of Targeting the CXCL10:CXCR3 Axis in Type 1 Diabetes Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis TOSO promotes β-cell proliferation and protects from apoptosis.Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival Expression of toll-like receptor 4 in maternal monocytes of patients with gestational diabetes mellitus.Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?β-MSCs: successful fusion of MSCs with β-cells results in a β-cell like phenotype.Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study.The role of the CXCL10/CXCR3 system in type 1 diabetes.MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.Bimodal impact of skeletal muscle on pancreatic β-cell function in health and disease.Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes.Toll-Like Receptor Activation in Immunity vs. Tolerance in Autoimmune Diabetes.Androgen receptor-deficient islet β-cells exhibit alteration in genetic markers of insulin secretion and inflammation. A transcriptome analysis in the male mouse.Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS.High Risk First Degree Relatives of Type 1 Diabetics: An Association with Increases in CXCR3(+) T Memory Cells Reflecting an Enhanced Activity of Th1 Autoimmune Response.Impact of Systemic Inflammation on the Progression of Gestational Diabetes Mellitus.

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P2860

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

http://www.wikidata.org/entity/Q45907066

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh-hant

name

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

@en

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

@nl

type

label

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

@en

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

@nl

prefLabel

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

@en

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

@nl

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J.CMET.2009.01.003

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Cell Metabolism

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CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

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Charles C King

http://www.w3.org/2001/XMLSchema#string

Fabienne T Schulthess

http://www.w3.org/2001/XMLSchema#string

Federico Paroni

http://www.w3.org/2001/XMLSchema#string

Jose Oberholzer

http://www.w3.org/2001/XMLSchema#string

Kathrin Maedler

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Leena Haataja

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Luan Shu

http://www.w3.org/2001/XMLSchema#string

Nadine S Sauter

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Pascale Ribaux

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Robert M Strieter

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125-139

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scholarly article

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10.1016/J.CMET.2009.01.003

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2

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9

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2009-02-01T00:00:00Z

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23971884

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19187771

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Toll-like receptor