CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
about
Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleedingKey role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flowPlatelet signaling: a complex interplay between inhibitory and activatory networksP2Y12 receptors: structure and functionA human platelet calcium calculator trained by pairwise agonist scanningVasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in plateletsThe kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation.CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia.von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3.CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexesRASA3 is a critical inhibitor of RAP1-dependent platelet activationG(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.CalDAG-GEFI and platelet activation.Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis.Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI.Thymoquinone-induced platelet apoptosis.Impact of elevated plasma serotonin on global gene expression of murine megakaryocytes.Regulation and Function of the RasGRP Family of Ras Activators in Blood CellsIntegrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi.Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signalingRap1-Rac1 circuits potentiate platelet activationExtracellular matrix proteins in hemostasis and thrombosisA negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation.Chlorin e6 Prevents ADP-Induced Platelet Aggregation by Decreasing PI3K-Akt Phosphorylation and Promoting cAMP Production.A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.Platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling and vascular integrity.Clopidogrel in acute coronary syndrome: implications of recent study findings.Platelet physiology and antiplatelet agents.Platelet receptor signaling in thrombus formation.P2Y12 receptor in platelet activation.Platelet signaling-a primer.Emerging roles of store-operated Ca²⁺ entry through STIM and ORAI proteins in immunity, hemostasis and cancer.Of von Willebrand factor and platelets.The P2X1 receptor and platelet function.RAP1-GTPase signaling and platelet function.Platelet immunoreceptor tyrosine-based activation motif (ITAM) and hemITAM signaling and vascular integrity in inflammation and development.New Concepts and Mechanisms of Platelet Activation Signaling.GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.
P2860
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P2860
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
@en
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
@nl
type
label
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
@en
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
@nl
prefLabel
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
@en
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
@nl
P1433
P1476
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
@en
P2093
R Claire Roden
Wolfgang Bergmeier
P304
P356
10.1182/BLOOD-2009-04-218768
P407
P577
2009-07-23T00:00:00Z