Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis.
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Structural Basis of Targeting the Exportin CRM1 in CancerMultiple Export Mechanisms for mRNAsNuclear export of proteins and drug resistance in cancerSelective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemiap53-Dependent anticancer effects of leptomycin B on lung adenocarcinomaSpecific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growthGenomic and molecular characterization of esophageal squamous cell carcinomaFirst-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid TumorsPhase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma.KPT-330 has antitumour activity against non-small cell lung cancer.Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.Atomic basis of CRM1-cargo recognition, release and inhibitionNovel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells.Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approachKPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma.Targeting nucleocytoplasmic transport in cancer therapyInhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agentsSINE (selective inhibitor of nuclear export)--translational science in a new class of anti-cancer agentsNucleo-cytoplasmic transport as a therapeutic target of cancershRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemiaComprehensive Evaluation of Nuclear Factor-κΒ Expression Patterns in Non-Small Cell Lung Cancer.Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesisThe Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compoundsExpression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential.Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemiaNovel reversible selective inhibitor of nuclear export shows that CRM1 is a target in colorectal cancer cells.Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT-330): A report from the pediatric preclinical testing program.Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells.CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells.Prognostic impact and targeting of CRM1 in acute myeloid leukemia.Chromosome region maintenance 1 expression and its association with clinical pathological features in primary carcinoma of the liver.CRM-1 knockdown inhibits extrahepatic cholangiocarcinoma tumor growth by blocking the nuclear export of p27Kip1.Preclinical activity of selinexor, an inhibitor of XPO1, in sarcomaCRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways.Prognostic significance of nuclear RNA export factor 3 in hepatocellular carcinoma.Expression of chromosomal regional maintenance protein-1 may be associated with subcellular survivin expression in human gastric and colorectal carcinoma.KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
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Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Expression of CRM1 in human gl ...... ession and clinical prognosis.
@en
Expression of CRM1 in human gl ...... ession and clinical prognosis.
@nl
type
label
Expression of CRM1 in human gl ...... ession and clinical prognosis.
@en
Expression of CRM1 in human gl ...... ession and clinical prognosis.
@nl
prefLabel
Expression of CRM1 in human gl ...... ession and clinical prognosis.
@en
Expression of CRM1 in human gl ...... ession and clinical prognosis.
@nl
P2093
P2860
P1433
P1476
Expression of CRM1 in human gl ...... ession and clinical prognosis.
@en
P2093
Aiguo Shen
Chun Cheng
Linlin Sun
Yuchan Wang
Yueming Zhao
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P304
153-9; discussion 159-60
P356
10.1227/01.NEU.0000348550.47441.4B
P407
P577
2009-07-01T00:00:00Z