Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea.
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Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapySingle cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice.Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethaneEfficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats.New and emerging technologies for genetic toxicity testing.Need and potential value of the Pig-ain vivo mutation assay-a HESI perspective.Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in ratsApplying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.A regenerative erythropoietic response does not increase the frequency of Pig-a mutant reticulocytes and erythrocytes in Sprague-Dawley rats.Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea.Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.Report on stage III Pig-a mutation assays using benzo[a]pyrene.Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment.Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats.Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes.Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.Assessment of genotoxicity induced by 7,12-dimethylbenz(a)anthracene or diethylnitrosamine in the Pig-a, micronucleus and Comet assays integrated into 28-day repeat dose studies.Establishing a novel Pig-a gene mutation assay in L5178YTk(+/-) mouse lymphoma cells.Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.Absence of in vivo genotoxicity of 3-monochloropropane-1,2-diol and associated fatty acid esters in a 4-week comprehensive toxicity study using F344 gpt delta rats.Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.The in vivo Pig-a gene mutation assay is useful for evaluating the genotoxicity of ionizing radiation in mice.Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea.Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.
P2860
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P2860
Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Accumulation and persistence o ...... oses of N-ethyl-N-nitrosourea.
@en
Accumulation and persistence o ...... oses of N-ethyl-N-nitrosourea.
@nl
type
label
Accumulation and persistence o ...... oses of N-ethyl-N-nitrosourea.
@en
Accumulation and persistence o ...... oses of N-ethyl-N-nitrosourea.
@nl
prefLabel
Accumulation and persistence o ...... oses of N-ethyl-N-nitrosourea.
@en
Accumulation and persistence o ...... oses of N-ethyl-N-nitrosourea.
@nl
P2093
P1433
P1476
Accumulation and persistence o ...... oses of N-ethyl-N-nitrosourea.
@en
P2093
Daishiro Miura
Robert H Heflich
Takafumi Kimoto
Vasily N Dobrovolsky
Yoshinori Kasahara
P356
10.1016/J.MRGENTOX.2009.05.014
P407
P577
2009-06-06T00:00:00Z