Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.
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Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cellsDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsNPAS3 demonstrates features of a tumor suppressive role in driving the progression of AstrocytomasCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryGlioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and RadioresistanceContemporary murine models in preclinical astrocytoma drug developmentLoss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era.Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low NeurotoxicityIDH1 mutation is sufficient to establish the glioma hypermethylator phenotypeNovel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomasIKK/NF-κB signaling contributes to glioblastoma stem cell maintenance.Metabotropic glutamate receptors as a new therapeutic target for malignant gliomasFoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytesDifferential expression of p42.3 in low- and high-grade gliomasSphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway.A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis.mTOR signaling in glioblastoma: lessons learned from bench to bedside.Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance.Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha.Quantitative proteomic analysis reveals effects of epidermal growth factor receptor (EGFR) on invasion-promoting proteins secreted by glioblastoma cells.Upregulator of cell proliferation predicts poor prognosis in hepatocellular carcinoma and contributes to hepatocarcinogenesis by downregulating FOXO3a.Somatic mutations of PIK3R1 promote gliomagenesis.Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model.A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesisAkt and c-Myc induce stem-cell markers in mature primary p53⁻/⁻ astrocytes and render these cells gliomagenic in the brain of immunocompetent mice.Astrocyte elevated gene-1 interacts with Akt isoform 2 to control glioma growth, survival, and pathogenesis.Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa.A unique model system for tumor progression in GBM comprising two developed human neuro-epithelial cell lines with differential transforming potential and coexpressing neuronal and glial markers.Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2.Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition.Comprehensive Glycomics of a Multistep Human Brain Tumor Model Reveals Specific Glycosylation Patterns Related to MalignancyInhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells.O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies.Silencing of phosphoglucose isomerase/autocrine motility factor decreases U87 human glioblastoma cell migration.MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma.The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells.High levels of phosphorylated MAP kinase are associated with poor survival among patients with glioblastoma during the temozolomide eraEstablishment of human iPSC-based models for the study and targeting of glioma initiating cells
P2860
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P2860
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Akt pathway activation convert ...... man astrocyte model of glioma.
@en
Akt pathway activation convert ...... man astrocyte model of glioma.
@nl
type
label
Akt pathway activation convert ...... man astrocyte model of glioma.
@en
Akt pathway activation convert ...... man astrocyte model of glioma.
@nl
prefLabel
Akt pathway activation convert ...... man astrocyte model of glioma.
@en
Akt pathway activation convert ...... man astrocyte model of glioma.
@nl
P2093
P1433
P1476
Akt pathway activation convert ...... uman astrocyte model of glioma
@en
P2093
P304
P407
P577
2001-09-01T00:00:00Z