Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. - Wikidata - awgldk - TriplyDB

Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity.

Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity.

http://www.wikidata.org/entity/Q46427128

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Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies Sirtuins in mammals: insights into their biological function Perspective: Does brown fat protect against diseases of aging?Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer's Disease Brain Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance.Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells.Uncoupling proteins, dietary fat and the metabolic syndrome Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications.Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor Silencing of uncoupling protein 2 by small interfering RNA aggravates mitochondrial dysfunction in cardiomyocytes under septic conditions.Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease.Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide.Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP(+))Dysregulated mitochondrial genes and networks with drug targets in postmortem brain of patients with posttraumatic stress disorder (PTSD) revealed by human mitochondria-focused cDNA microarrays.Mutant huntingtin and mitochondrial dysfunction.Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation.UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis.Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection.Mitochondrial ROS signaling in organismal homeostasis.Involvement of Astrocytes in Mediating the Central Effects of Ghrelin.DNP, mitochondrial uncoupling, and neuroprotection: A little dab'll do ya.GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival.Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats.Ghrelin is neuroprotective in Parkinson's disease: molecular mechanisms of metabolic neuroprotection.UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis.The Impact of Ghrelin in Metabolic Diseases: An Immune Perspective Less is more: Caloric regulation of neurogenesis and adult brain function.'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress.PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells.

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Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity.

http://www.wikidata.org/entity/Q46427128

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2005 nî lūn-bûn

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Uncoupling protein 2 protects ...... l-tetrahydropyridine toxicity.

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Uncoupling protein 2 protects ...... l-tetrahydropyridine toxicity.

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Uncoupling protein 2 protects ...... l-tetrahydropyridine toxicity.

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Uncoupling protein 2 protects ...... l-tetrahydropyridine toxicity.

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J.1471-4159.2005.03052.X

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Journal of Neurochemistry

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Uncoupling protein 2 protects ...... l-tetrahydropyridine toxicity.

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Alasdair M Barr

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Covadonga Paneda

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Flint Beal

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Jacinta Lucero

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Janell Pemberton

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M Margarita Behrens

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Pamela Maher

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Pietro Paolo Sanna

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Raphaelle Winsky-Sommerer

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Sebastian A Wirz

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P2860

BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast

UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Energy metabolism in uncoupling protein 3 gene knockout mice

Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS

Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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2

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93

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Zane B. Andrews

Raphaelle Winsky-Sommerer

Maria Concetta Morale

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2005-04-01T00:00:00Z

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7919565

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15816872

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