HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
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Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID miceA phase 2 study of vorinostat in acute myeloid leukemiaTargeting p97 to Disrupt Protein Homeostasis in CancerHistone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancySynergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivoPreclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas.Histone acetylation and reactive oxygen species are involved in the preprophase arrest induced by sodium butyrate in maize roots.Mechanism-anchored profiling derived from epigenetic networks predicts outcome in acute lymphoblastic leukemiaIIp45 inhibits cell migration through inhibition of HDAC6Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage.SAHA and S116836, a novel tyrosine kinase inhibitor, synergistically induce apoptosis in imatinib-resistant chronic myelogenous leukemia cells.Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.A novel class of small molecule inhibitors of HDAC6.Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia.Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulationHeat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug.Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agentsHeat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemiasHistone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.Bioactive metabolites from Chaetomium aureum: structure elucidation and inhibition of the Hsp90 machine chaperoning activity.Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinicSyntheses and discovery of a novel class of cinnamic hydroxamates as histone deacetylase inhibitors by multimodality molecular imaging in living subjects.Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleftWTAP is a novel oncogenic protein in acute myeloid leukemiaPhase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia.Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast CancerHDAC expression and activity is upregulated in diseased lupus-prone mice.Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia.Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.A stress protein interface of innate immunity.HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells.New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas.A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation.Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells.Histone deacetylases: a saga of perturbed acetylation homeostasis in cancer.Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition.
P2860
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P2860
HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
HDAC6 inhibition enhances 17-A ...... ction in human leukemia cells.
@en
HDAC6 inhibition enhances 17-A ...... ction in human leukemia cells.
@nl
type
label
HDAC6 inhibition enhances 17-A ...... ction in human leukemia cells.
@en
HDAC6 inhibition enhances 17-A ...... ction in human leukemia cells.
@nl
prefLabel
HDAC6 inhibition enhances 17-A ...... ction in human leukemia cells.
@en
HDAC6 inhibition enhances 17-A ...... ction in human leukemia cells.
@nl
P2093
P1433
P1476
HDAC6 inhibition enhances 17-A ...... ction in human leukemia cells.
@en
P2093
Aditya Mandawat
James E Bradner
Kapil Bhalla
Peter Atadja
Pravina Fernandez
Rajeshree Joshi
Warren Fiskus
Yonghua Yang
P304
P356
10.1182/BLOOD-2008-03-143644
P407
P577
2008-06-30T00:00:00Z