Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
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PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilastPDE4 inhibitors: current statusEffect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice.Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophagesInflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation.Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Pharmacological characterisation of anti-inflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation.Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs.A novel nonhuman primate model of cigarette smoke-induced airway diseaseInhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse modelAirway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.Effects of second hand smoke on airway secretion and mucociliary clearance.Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities.Update in chronic obstructive pulmonary disease 2005.Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of respiratory disease.Current concepts in mechanisms of emphysema.Tobacco smoke induced COPD/emphysema in the animal model-are we all on the same page?Mechanisms of cigarette smoke-induced COPD: insights from animal models.Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease.COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention.Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease.Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease.Roflumilast in chronic obstructive pulmonary disease: evidence from large trials.Treatment of chronic obstructive pulmonary disease with roflumilast, a new phosphodiesterase 4 inhibitor.Preclinical animal models of asthma and chronic obstructive pulmonary disease.Mitigation of chlorine lung injury by increasing cyclic AMP levelsRoflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary diseaseNew therapeutic options in the management of COPD - focus on roflumilast.Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use?PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.Emerging drugs for chronic obstructive pulmonary disease.Phosphodiesterase-4 inhibitor therapy for lung diseases.Roflumilast : the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD.Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases.Animal models for anti-emphysema drug discovery.Roflumilast: A Review in COPD.Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model.The discovery of roflumilast for the treatment of chronic obstructive pulmonary disease.Roflumilast, a Novel Phosphodiesterase 4 Inhibitor, for COPD Patients with a History of Exacerbations.
P2860
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P2860
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
@en
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
@nl
type
label
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
@en
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
@nl
prefLabel
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
@en
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
@nl
P2093
P2860
P1476
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
@en
P2093
Giuseppe Lungarella
Lutz Wollin
Monica Lucattelli
Piero A Martorana
Rolf Beume
P2860
P304
P356
10.1164/RCCM.200411-1549OC
P407
P577
2005-06-16T00:00:00Z