Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. - Wikidata - awgldk - TriplyDB

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

http://www.wikidata.org/entity/Q46551607

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PDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilast PDE4 inhibitors: current status Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice.Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation.Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Pharmacological characterisation of anti-inflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation.Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs.A novel nonhuman primate model of cigarette smoke-induced airway disease Inhibitory effects of Stemona tuberosa on lung inflammation in a subacute cigarette smoke-induced mouse model Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.Effects of second hand smoke on airway secretion and mucociliary clearance.Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities.Update in chronic obstructive pulmonary disease 2005.Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of respiratory disease.Current concepts in mechanisms of emphysema.Tobacco smoke induced COPD/emphysema in the animal model-are we all on the same page?Mechanisms of cigarette smoke-induced COPD: insights from animal models.Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease.COPD as a lung disease with systemic consequences--clinical impact, mechanisms, and potential for early intervention.Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease.Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease.Roflumilast in chronic obstructive pulmonary disease: evidence from large trials.Treatment of chronic obstructive pulmonary disease with roflumilast, a new phosphodiesterase 4 inhibitor.Preclinical animal models of asthma and chronic obstructive pulmonary disease.Mitigation of chlorine lung injury by increasing cyclic AMP levels Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease New therapeutic options in the management of COPD - focus on roflumilast.Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use?PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.Emerging drugs for chronic obstructive pulmonary disease.Phosphodiesterase-4 inhibitor therapy for lung diseases.Roflumilast : the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD.Dual PDE3/4 and PDE4 inhibitors: novel treatments for COPD and other inflammatory airway diseases.Animal models for anti-emphysema drug discovery.Roflumilast: A Review in COPD.Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model.The discovery of roflumilast for the treatment of chronic obstructive pulmonary disease.Roflumilast, a Novel Phosphodiesterase 4 Inhibitor, for COPD Patients with a History of Exacerbations.

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P2860

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

http://www.wikidata.org/entity/Q46551607

description

2005 nî lūn-bûn

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2005年学术文章

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2005年學術文章

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name

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

@en

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

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type

label

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

@en

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

@nl

prefLabel

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

@en

Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

@nl

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Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.

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Giuseppe Lungarella

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Lutz Wollin

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Monica Lucattelli

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Piero A Martorana

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Rolf Beume

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P2860

Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study

In patients with chronic bronchitis a four week trial with inhaled steroids does not attenuate airway inflammation.

Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.

Enrichment and analysis of desmosine and isodesmosine in biological fluids.

Urinary excretion reflects lung deposition of aminoglycoside aerosols in cystic fibrosis.

Molecular mechanisms of decreased steroid responsiveness induced by latent adenoviral infection in allergic lung inflammation.

Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice.

Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase.

alpha-1-Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse.

Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse.

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