Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells.
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Hypoxia: The Force that Drives Chronic Kidney DiseaseThe proximal tubule is the primary target of injury and progression of kidney disease: role of the glomerulotubular junction.Increased Retinal Oxygen Metabolism Precedes Microvascular Alterations in Type 1 Diabetic Mice.Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.Nitric oxide originating from NOS1 controls oxygen utilization and electrolyte transport efficiency in the diabetic kidney.Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.Acute knockdown of uncoupling protein-2 increases uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneysAutophagy in diabetic nephropathyThe proximal tubule in the pathophysiology of the diabetic kidney.Activation of hypoxia-inducible factors prevents diabetic nephropathy.Protective role of PGC-1α in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling.Polymorphisms of the UCP2 Gene Are Associated with Glomerular Filtration Rate in Type 2 Diabetic Patients and with Decreased UCP2 Gene Expression in Human Kidney.NADPH oxidase inhibition reduces tubular sodium transport and improves kidney oxygenation in diabetes.Light-emitting diode modulates carbohydrate metabolism by pancreatic duct regeneration.A glimpse of various pathogenetic mechanisms of diabetic nephropathy.Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complicationsKidney hypoxia, attributable to increased oxygen consumption, induces nephropathy independently of hyperglycemia and oxidative stress.Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring.Determinants of kidney oxygen consumption and their relationship to tissue oxygen tension in diabetes and hypertension.Hyperbaric oxygen therapy reduces renal lactate production.Pathophysiology of the diabetic kidney.Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia.Angiotensin II reduces transport-dependent oxygen consumption but increases transport-independent oxygen consumption in immortalized mouse proximal tubular cells.Mitochondrial Reactive Oxygen Species and Kidney Hypoxia in the Development of Diabetic NephropathyAcute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats.Kidney function after in vivo gene silencing of uncoupling protein-2 in streptozotocin-induced diabetic rats.Platelets of type 2 diabetic patients are characterized by high ATP content and low mitochondrial membrane potential.Downregulation of uncoupling protein-2 by genipin exacerbates diabetes-induced kidney proximal tubular cells apoptosis.Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes.Renal transplantation induces mitochondrial uncoupling, increased kidney oxygen consumption, and decreased kidney oxygen tension.Endothelin type A receptor inhibition normalises intrarenal hypoxia in rats used as a model of type 1 diabetes by improving oxygen delivery.Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-C]Pyruvate MRICoenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes
P2860
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P2860
Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Diabetes-induced up-regulation ...... kidney proximal tubular cells.
@en
Diabetes-induced up-regulation ...... kidney proximal tubular cells.
@nl
type
label
Diabetes-induced up-regulation ...... kidney proximal tubular cells.
@en
Diabetes-induced up-regulation ...... kidney proximal tubular cells.
@nl
prefLabel
Diabetes-induced up-regulation ...... kidney proximal tubular cells.
@en
Diabetes-induced up-regulation ...... kidney proximal tubular cells.
@nl
P2093
P1476
Diabetes-induced up-regulation ...... kidney proximal tubular cells
@en
P2093
Angelica Fasching
Fredrik Palm
Malou Friederich
P304
P356
10.1016/J.BBABIO.2008.03.030
P577
2008-04-07T00:00:00Z