Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.
about
Specificity in Ras and Rap signalingT cell activationThe ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1Integrin cytoplasmic tail interactionsBone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activationDesign, Synthesis, and Biological Evaluation of PKD Inhibitors.MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo.LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter proteinProtein kinase D as a potential new target for cancer therapy.T-cell receptor signaling to integrins.Impairment of immunological synapse formation in adaptively tolerant T cellsProtein kinase D signaling: multiple biological functions in health and disease.Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells.The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2Derepression of pathological cardiac genes by members of the CaM kinase superfamily.Diacylglycerol kinases: regulated controllers of T cell activation, function, and development.Tec kinases, actin, and cell adhesion.Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules.Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.Platelet integrins and immunoreceptors.The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.The ins and outs of leukocyte integrin signaling.Cell migration: regulation of cytoskeleton by Rap1 in Dictyostelium discoideum.Physiological functions of protein kinase D in vivo.Mechanisms of talin-dependent integrin signaling and crosstalkProtein kinase D1 inhibits cell proliferation through matrix metalloproteinase-2 and matrix metalloproteinase-9 secretion in prostate cancer.The SLP-76 Src homology 2 domain is required for T cell development and activation.Crosstalk of cell polarity signaling pathways.Pharmacological activation of guanine nucleotide exchange factors for the small GTPase Rap1 recruits high-affinity beta1 integrins as coreceptors for parvovirus B19: improved ex vivo gene transfer to human erythroid progenitor cells.Protein kinase D signaling in cancer: A friend or foe?Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.Protein kinase D is an essential regulator of C. elegans innate immunity.WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes.
P2860
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P2860
Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Protein kinase D1 and the beta ...... regulation of Rap1 activation.
@en
Protein kinase D1 and the beta ...... regulation of Rap1 activation.
@nl
type
label
Protein kinase D1 and the beta ...... regulation of Rap1 activation.
@en
Protein kinase D1 and the beta ...... regulation of Rap1 activation.
@nl
prefLabel
Protein kinase D1 and the beta ...... regulation of Rap1 activation.
@en
Protein kinase D1 and the beta ...... regulation of Rap1 activation.
@nl
P2093
P1433
P1476
Protein kinase D1 and the beta ...... regulation of Rap1 activation
@en
P2093
Angie C Quale
Daniel D Billadeau
Deborah M Dickey
Heekyoung Chung
Lakshmi R Nagarajan
Ricardo B Medeiros
P304
P356
10.1016/J.IMMUNI.2005.07.006
P407
P50
P577
2005-08-01T00:00:00Z