Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.
about
Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motifInhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifsIRF7: activation, regulation, modification and functionThe Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and AutoimmunityTyrosine phosphorylation in Toll-like receptor signalingInterleukin-1 loop model for pathogenesis of Langerhans cell histiocytosisCD244 is expressed on dendritic cells and regulates their functionsComprehensive logic based analyses of Toll-like receptor 4 signal transduction pathwayIntracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase BtkLILRA2 selectively modulates LPS-mediated cytokine production and inhibits phagocytosis by monocytesSOCS2 influences LPS induced human monocyte-derived dendritic cell maturation.CD47 and TLR-2 cross-talk regulates neutrophil transmigration.Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells.Programmed death 1 deficiency induces the polarization of macrophages/microglia to the M1 phenotype after spinal cord injury in mice.Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritisReal-time imaging and genetic dissection of host-microbe interactions in zebrafish.MiR-21 plays an important role in radiation induced carcinogenesis in BALB/c mice by directly targeting the tumor suppressor gene Big-h3.MicroRNA-146 function in the innate immune transcriptome response of zebrafish embryos to Salmonella typhimurium infection.Mediators of Tyrosine Phosphorylation in Innate Immunity: From Host Defense to Inflammation onto Oncogenesis.The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) productionAn HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells.Toll-like receptors in liver fibrosis: cellular crosstalk and mechanismsThe intracerebroventricular injection of rimonabant inhibits systemic lipopolysaccharide-induced lung inflammation.Update on the immunological pathway of negative regulation in acute insults and sepsisSTK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease.Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional ProgramNegative regulatory approaches to the attenuation of Toll-like receptor signaling.B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells.Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten miceClec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity.Identification of miRNomes reveals ssc-miR-30d-R_1 as a potential therapeutic target for PRRS viral infection.A critical role of toll-like receptor 4 (TLR4) and its' in vivo ligands in basal radio-resistance.Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.Regulation of the inflammatory response in cardiac repairProtection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting proteinPPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1.TLRs and innate immunity.Kupffer cells in non-alcoholic fatty liver disease: the emerging view.Pattern-recognition receptor signaling regulator mRNA expression in humans and mice, and in transient inflammation or progressive fibrosis
P2860
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P2860
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Phosphatase SHP-1 promotes TLR ...... y inhibiting the kinase IRAK1.
@en
Phosphatase SHP-1 promotes TLR ...... y inhibiting the kinase IRAK1.
@nl
type
label
Phosphatase SHP-1 promotes TLR ...... y inhibiting the kinase IRAK1.
@en
Phosphatase SHP-1 promotes TLR ...... y inhibiting the kinase IRAK1.
@nl
prefLabel
Phosphatase SHP-1 promotes TLR ...... y inhibiting the kinase IRAK1.
@en
Phosphatase SHP-1 promotes TLR ...... y inhibiting the kinase IRAK1.
@nl
P2093
P2860
P356
P1433
P1476
Phosphatase SHP-1 promotes TLR ...... y inhibiting the kinase IRAK1.
@en
P2093
Hongmei Xu
Huazhang An
Shuxun Liu
Xuetao Cao
Yuejuan Zheng
P2860
P304
P356
10.1038/NI.1604
P407
P50
P577
2008-04-06T00:00:00Z