Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis.
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mTOR signaling in growth control and diseaseIntracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseasesCharacterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegansOverexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph diseaseBeclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseasesAutophagy: cerebral home cooking.Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragmentsRapamycin promotes Schwann cell migration and nerve growth factor secretion.A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast.Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model tQuantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters.Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins.The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeuticsSerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice.Inhibition of mTOR Pathway by Rapamycin Reduces Brain Damage in Rats Subjected to Transient Forebrain Ischemia.Autophagy in neuroprotection and neurodegeneration: A question of balance.Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease.Autophagy in axonal and dendritic degeneration.Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP⁺-induced apoptosis but not rotenone or 6-hydroxydopamine toxicityAutophagy: regulation and role in disease.Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells.mTOR's role in ageing: protein synthesis or autophagy?TOR on the brain.Monitoring autophagy in the treatment of protein aggregate diseases: steps toward identifying autophagic biomarkers.Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain.The chondrocytic journey in endochondral bone growth and skeletal dysplasia.Recent insights on principles of synaptic protein degradationIn vitro and in vivo aggregation of a fragment of huntingtin protein directly causes free radical production.Role of mammalian target of rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse-prone 8 model.Inhibition of mTOR signaling Confers Protection against Cerebral Ischemic Injury in Acute Hyperglycemic RatsFunctional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.Is modulating translation a therapeutic option for Huntington's disease?Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.The Aggregation of Huntingtin and α-Synuclein.Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.The effects of proteasomal inhibition on synaptic proteostasis.
P2860
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P2860
Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Rapamycin inhibits polyglutami ...... by reducing protein synthesis.
@en
Rapamycin inhibits polyglutami ...... by reducing protein synthesis.
@nl
type
label
Rapamycin inhibits polyglutami ...... by reducing protein synthesis.
@en
Rapamycin inhibits polyglutami ...... by reducing protein synthesis.
@nl
prefLabel
Rapamycin inhibits polyglutami ...... by reducing protein synthesis.
@en
Rapamycin inhibits polyglutami ...... by reducing protein synthesis.
@nl
P2093
P356
P1476
Rapamycin inhibits polyglutami ...... by reducing protein synthesis.
@en
P2093
Andreas Wyttenbach
Aviva M Tolkovsky
Farida Hafiz
Matthew A King
Sarah Hands
P304
P356
10.1124/MOL.107.043398
P577
2008-01-16T00:00:00Z