Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids. - Wikidata - awgldk - TriplyDB

Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.

Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.

http://www.wikidata.org/entity/Q46835051

about

Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades Farnesoid X Receptor an Emerging Target to Combat Obesity.Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice.Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice.Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome.Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null mice Deciphering the nuclear bile acid receptor FXR paradigm.Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice.Cholestasis induces reversible accumulation of periplakin in mouse liver.Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice Benefit of farnesoid X receptor inhibition in obstructive cholestasis.Intestinal transport and metabolism of bile acids Effect of bile duct ligation on bile acid composition in mouse serum and liver Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling.Elevated copper impairs hepatic nuclear receptor function in Wilson's disease.Novel insight into mechanisms of cholestatic liver injury.Drug disposition alterations in liver disease: extrahepatic effects in cholestasis and nonalcoholic steatohepatitis.FXR: a target for cholestatic syndromes?FXR and PXR: potential therapeutic targets in cholestasis.The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation.Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.Suppression of autophagic flux by bile acids in hepatocytes.Hepatobiliary membrane transporters in primary biliary cirrhosis.The interplay between retinoic acid receptor-related orphan receptors and human diseases.Nuclear receptors in bile acid metabolism 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression.Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis.Simvastatin protects against cholestasis-induced liver injury.Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis.Cyp3a11 is not essential for the formation of murine bile acids.Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis.

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P2860

Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids.

http://www.wikidata.org/entity/Q46835051

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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name

Fxr

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Fxr(-/-) mice adapt to biliary ...... nal elimination of bile acids.

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Fxr(-/-) mice adapt to biliary ...... nal elimination of bile acids.

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Fxr

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Fxr(-/-) mice adapt to biliary ...... nal elimination of bile acids.

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JLR.M500427-JLR200

P1433

Journal of Lipid Research

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Fxr(-/-) mice adapt to biliary ...... nal elimination of bile acids.

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P2093

Andrea Fuchsbichler

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Dagmar Silbert

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Hanns-Ulrich Marschall

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Jan Sjövall

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Judith Gumhold

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Karl Bodin

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Martin Wagner

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Michael Trauner

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P2860

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

The enzymes, regulation, and genetics of bile acid synthesis

Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein

Bile acid metabolism.

Bile salt transporters: molecular characterization, function, and regulation.

6 alpha-glucuronidation of hyodeoxycholic acid by human liver, kidney and small bowel microsomes.

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.

Bile acid profiles in urine of patients with liver diseases.

Urinary bile acids in late pregnancy and in recurrent cholestasis of pregnancy.

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3

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47

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16327028

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