Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
about
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesA genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stabilityTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyTti1 and Tel2 are critical factors in mammalian target of rapamycin complex assemblyCharacterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline developmentTel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCalpha.TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdomSynergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter.Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complexTORC2-a new player in genome stabilityGenetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.Rab-family GTPase regulates TOR complex 2 signaling in fission yeastThe selective elimination of messenger RNA underlies the mitosis-meiosis switch in fission yeast.Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphateMechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TORRab small GTPase emerges as a regulator of TOR complex 2Klf1, a C2H2 zinc finger-transcription factor, is required for cell wall maintenance during long-term quiescence in differentiated G0 phaseWat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombeChemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteomeTor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission YeastFission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission YeastGenetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognitionFission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucoseSte12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control.Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinaseATM-like kinases and regulation of telomerase: lessons from yeast and mammalsThe S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.TORC1 signaling is governed by two negative regulators in fission yeast.Signaling cascades as drug targets in model and pathogenic fungi.Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
P2860
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P2860
Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Rapamycin sensitivity of the S ...... specific and common subunits.
@en
Rapamycin sensitivity of the S ...... specific and common subunits.
@nl
type
label
Rapamycin sensitivity of the S ...... specific and common subunits.
@en
Rapamycin sensitivity of the S ...... specific and common subunits.
@nl
prefLabel
Rapamycin sensitivity of the S ...... specific and common subunits.
@en
Rapamycin sensitivity of the S ...... specific and common subunits.
@nl
P2093
P2860
P1433
P1476
Rapamycin sensitivity of the S ...... specific and common subunits.
@en
P2093
Aya Kokubu
Junko Kanoh
Masahiro Ebe
Mitsuhiro Yanagida
Mitsuko Hatanaka
Takeshi Hayashi
Yukinobu Nakaseko
P2860
P304
P356
10.1111/J.1365-2443.2007.01141.X
P50
P577
2007-12-01T00:00:00Z