The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action.
about
Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungsThioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aureus USA300A multi-level multi-scale approach to study essential genes in Mycobacterium tuberculosistargetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysisThe mechanism of action of PA-824: Novel insights from transcriptional profilingDesign, synthesis, and evaluation of novel ethambutol analoguesPA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO releaseTuberculosis drug discovery in the post-post-genomic eraTranslating genomics research into control of tuberculosis: lessons learned and future prospectsThe enduring hypoxic response of Mycobacterium tuberculosisGenomic and transcriptomic analysis of the streptomycin-dependent Mycobacterium tuberculosis strain 18b.Learning from the past for TB drug discovery in the futureAn Extracellular Disulfide Bond Forming Protein (DsbF) from Mycobacterium tuberculosis: Structural, Biochemical, and Gene Expression AnalysisBiochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated VariantsIdentification of a small molecule with activity against drug-resistant and persistent tuberculosisPrioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosisTranscriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosisA Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazineA genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolatesInterpreting expression data with metabolic flux models: predicting Mycobacterium tuberculosis mycolic acid productionHypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccinesSequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosisRv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificityDifferential producibility analysis (DPA) of transcriptomic data with metabolic networks: deconstructing the metabolic response of M. tuberculosisThe regulation of sulfur metabolism in Mycobacterium tuberculosisThe two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activitiesHeterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZBenzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesisAn immunomodulatory role for the Mycobacterium tuberculosis region of difference 1 locus proteins PE35 (Rv3872) and PPE68 (Rv3873)DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulonThe nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by DxsSelf-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathwaySurface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophagesFunction and regulation of class I ribonucleotide reductase-encoding genes in mycobacteriaCarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistenceBiosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilliInactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulenceMycobacterium tuberculosis MT2816 encodes a key stress-response regulatorMycobacterium tuberculosis WhiB3 responds to O2 and nitric oxide via its [4Fe-4S] cluster and is essential for nutrient starvation survivalFunctional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH
P2860
Q21089606-2C4891E7-5668-4E73-B17F-236D3044241FQ21133515-F7A28EDD-E5BA-4642-9DA9-0022A5476189Q21202770-8AA030AA-10A1-43E4-98EA-597E505F19ECQ21202793-F97DEF71-EE33-42F1-A069-3EADBB3FD52DQ24643238-995B115C-8BD1-4E18-95AE-48D187D439B3Q24648486-B473DB28-AC0D-4770-AA01-E6CD87146311Q24654913-8224A4AE-7D39-4FB3-9B00-78F7E716B0C0Q26864729-A8F8D2C3-CF26-462E-9495-886D70228C65Q27023437-ACFF5F93-AC5D-4291-8158-E800517697A0Q27302134-684894C3-FD5A-4283-8B7D-BE721FF7DCBCQ27316642-EF7B5886-415C-451D-BD54-A3276FEBBDDAQ27485405-43EBCCBA-7E74-4518-8979-0641E6BA9A0AQ27658897-892D6F49-504F-4577-96A2-C690108F09E7Q27677244-9B950FD3-A6BF-4461-8043-F6B9CB081E31Q27678663-1F4396A1-62C6-4DFF-9F1A-C3C301F04686Q28469010-E7E19A7A-9A2D-4D3A-BB3D-104A672ABE47Q28469237-B14BD4B7-BC81-4954-8514-0995286E3B2DQ28473609-896C9C6C-9366-4CBC-A01C-28F48983568AQ28474023-8A43CB09-9E15-468D-9359-A341741C8211Q28475985-53CF5613-8FDD-41F3-A3EB-F7B19F0E521DQ28476626-BE74DAF2-1290-411A-B4E2-7510068E6C04Q28477804-B75DA64C-6735-4AAE-8356-7E6FDFB3C6C4Q28477960-C47EB95F-071B-4C05-A209-7394A9F7C080Q28478889-7843F75E-3E3B-4EA0-91C1-EB29328814CFQ28479234-4064A3F5-38A9-4EFB-843B-77236FA80DFFQ28482089-07E7FF14-9A57-48E1-9090-AD11CC5E56ADQ28486330-3B93E830-9EB6-4D49-9D6A-5150D2EB0589Q28486345-5BB792FE-388E-4084-B302-DE6AE30917CFQ28486390-B96A1899-700C-40CA-9D8A-306E9C5E1212Q28486525-C8E2791A-EE0C-48B9-841E-4F7BEBCE0E5DQ28486627-FBF393F4-5D5C-46FA-A1A8-F837F742545BQ28486696-8BEC0EAC-AA40-4576-B407-0F94D4A7BE70Q28486781-C4E1B012-7A2C-41D5-A250-3E0B7C47C273Q28486854-0D246D29-0DDA-4FDF-9B3C-297C54810F19Q28486907-F2EDB464-72B7-431D-A717-D03E03C29056Q28487010-398B3BCB-B9C4-4978-9EE1-AD2B08057259Q28487054-F4688017-3FAA-4A47-86C7-337B2002F700Q28487103-709E9CC2-231B-45C7-8BEF-B111BEF6F356Q28487104-FF177547-7EC1-4E93-958A-7F5E9CC9D6A6Q28487106-39F94044-713A-4227-8911-EDC14FDC0409
P2860
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
The transcriptional responses ...... nto drug mechanisms of action.
@en
The transcriptional responses ...... nto drug mechanisms of action.
@nl
type
label
The transcriptional responses ...... nto drug mechanisms of action.
@en
The transcriptional responses ...... nto drug mechanisms of action.
@nl
prefLabel
The transcriptional responses ...... nto drug mechanisms of action.
@en
The transcriptional responses ...... nto drug mechanisms of action.
@nl
P2093
P2860
P356
P1476
The transcriptional responses ...... nto drug mechanisms of action.
@en
P2093
Helena I M Boshoff
Michael A Wilson
Michael R McNeil
Timothy G Myers
P2860
P304
40174-40184
P356
10.1074/JBC.M406796200
P407
P577
2004-07-09T00:00:00Z