Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.
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Tau-tubulin kinaseComparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's diseaseEarly axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice.A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluationIncreased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalitiesASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegenerationCytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.The cytoskeleton in neurodegenerative diseases.Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease.An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic miceDysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic targetChanges in the ageing brain in health and disease.Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation.Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's diseaseStable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice.Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.Absence of ubiquitinated inclusions in hypocretin neurons of patients with narcolepsy.Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.Insulin dysfunction and Tau pathology.Significance and limitation of the pathological classification of TDP-43 proteinopathy.Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb.Tau gene mutation K257T causes a tauopathy similar to Pick's disease.Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein.Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.Heparin-induced conformational change in microtubule-associated protein Tau as detected by chemical cross-linking and phosphopeptide mapping.Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport.Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy.The tauopathies: toward an experimental animal model.Spinal cord neurofibrillary pathology in Alzheimer disease and Guam Parkinsonism-dementia complex.Abnormal Tau phosphorylation of the Alzheimer-type also occurs during mitosis.What is the evidence that tau pathology spreads through prion-like propagation?Xanthoceraside attenuates tau hyperphosphorylation and cognitive deficits in intracerebroventricular-streptozotocin injected rats.Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration.Hierarchical phosphorylation of recombinant tau by the paired-helical filament-associated protein kinase is dependent on cyclic AMP-dependent protein kinase.Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.Formation of phospho-SAPK/JNK granules in the hippocampus is an early event in Alzheimer disease.
P2860
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P2860
Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Characterization of mAb AP422, ...... antibody against tau protein.
@en
Characterization of mAb AP422, ...... antibody against tau protein.
@nl
type
label
Characterization of mAb AP422, ...... antibody against tau protein.
@en
Characterization of mAb AP422, ...... antibody against tau protein.
@nl
prefLabel
Characterization of mAb AP422, ...... antibody against tau protein.
@en
Characterization of mAb AP422, ...... antibody against tau protein.
@nl
P2093
P2860
P1433
P1476
Characterization of mAb AP422, ...... antibody against tau protein.
@en
P2093
P2860
P356
10.1016/0014-5793(96)00271-2
P407
P577
1996-04-01T00:00:00Z