Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities.
about
General anaesthetic actions on ligand-gated ion channels5-HT3 receptorsThe nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamilyChanging channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitabilityNeuronal nicotinic receptors: from protein structure to functionOpen probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancyThe interaction of trichloroethanol with murine recombinant 5-HT3 receptorsPromiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channelsStructural features of the ligand-binding domain of the serotonin 5HT3 receptorCharacterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cellsMouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domainPredicted structure of the extracellular region of ligand-gated ion-channel receptors shows SH2-like and SH3-like domains forming the ligand-binding siteMechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure.The emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor.Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation.Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.Volatile anesthetics and endogenous cannabinoid anandamide have additive and independent inhibitory effects on alpha(7)-nicotinic acetylcholine receptor-mediated responses in Xenopus oocytesIdentification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors.The binding orientation of epibatidine at α7 nACh receptorsELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.The binding orientations of structurally-related ligands can differ; A cautionary noteA study of AroP-PheP chimeric proteins and identification of a residue involved in tryptophan transportCharacterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors.The influence of a chronic adolescent nicotine exposure on ethanol withdrawal severity during adulthood in C3H mice.Acetylcholine receptors and myasthenia.Homology modeling and molecular dynamics simulations of the glycine receptor ligand binding domainReceptor targeting and heterogeneity at interneuronal nicotinic cholinergic synapses in vivo.Chemical and genetic engineering of selective ion channel-ligand interactionsPore conformations and gating mechanism of a Cys-loop receptor.The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancerRic-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER subcompartment of dendrites.Homology model of the GABAA receptor examined using Brownian dynamicsMolecular tuning of fast gating in pentameric ligand-gated ion channels.The Drosophila nicotinic acetylcholine receptor subunits Dα5 and Dα7 form functional homomeric and heteromeric ion channelsNicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranesIdentification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domainDual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors.The use of electrophysiology to improve understanding of drug-receptor interactions.Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors.A method for soluble overexpression of the alpha7 nicotinic acetylcholine receptor extracellular domain.
P2860
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P2860
Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh-hant
name
Chimaeric nicotinic-serotonerg ...... ing and channel specificities.
@en
Chimaeric nicotinic-serotonerg ...... ing and channel specificities.
@nl
type
label
Chimaeric nicotinic-serotonerg ...... ing and channel specificities.
@en
Chimaeric nicotinic-serotonerg ...... ing and channel specificities.
@nl
prefLabel
Chimaeric nicotinic-serotonerg ...... ing and channel specificities.
@en
Chimaeric nicotinic-serotonerg ...... ing and channel specificities.
@nl
P2093
P356
P1433
P1476
Chimaeric nicotinic-serotonerg ...... ing and channel specificities.
@en
P2093
Bertrand D
Bertrand S
Changeux JP
Devillers-Thiéry A
P2888
P304
P356
10.1038/366479A0
P407
P577
1993-12-01T00:00:00Z
P6179
1030007131