Homology model of the GABAA receptor examined using Brownian dynamics
about
A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sitesNovel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptorsMolecular dynamics simulation studies of GLUT4: substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibitionIon conduction in ligand-gated ion channels: Brownian dynamics studies of four recent crystal structures.A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.Testing the applicability of Nernst-Planck theory in ion channels: comparisons with Brownian dynamics simulations.Synthetic chloride-selective carbon nanotubes examined by using molecular and stochastic dynamics.Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.Engineering a light-regulated GABAA receptor for optical control of neural inhibition.Structural model for gamma-aminobutyric acid receptor noncompetitive antagonist binding: widely diverse structures fit the same siteA state-dependent salt-bridge interaction exists across the β/α intersubunit interface of the GABAA receptor.Three arginines in the GABAA receptor binding pocket have distinct roles in the formation and stability of agonist- versus antagonist-bound complexesA tight coupling between β₂Y97 and β₂F200 of the GABA(A) receptor mediates GABA bindingStoichiometric pore mutations of the GABAAR reveal a pattern of hydrogen bonding with picrotoxin.Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.Modeling neuronal nicotinic and GABA receptors: important interface salt-links and protein dynamics.Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.Pharmacophore models for GABA(A) modulators: implications in CNS drug discovery.Probing the orthosteric binding site of GABAA receptors with heterocyclic GABA carboxylic acid bioisosteres.Spontaneous mobility of GABAA receptor M2 extracellular half relative to noncompetitive antagonist action.Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents.Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor.Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives.An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits.Gaba receptor insecticide non-competitive antagonists may bind at allosteric modulator sites.Role of Bioinformatics in the Study of Ionic Channels.Pyrazolo[1,5-a]quinazoline scaffold as 5-deaza analogue of pyrazolo[5,1-c][1,2,4]benzotriazine system: synthesis of new derivatives, biological activity on GABAA receptor subtype and molecular dynamic study.Molecular determinants of ginkgolide binding in the glycine receptor pore
P2860
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P2860
Homology model of the GABAA receptor examined using Brownian dynamics
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Homology model of the GABAA receptor examined using Brownian dynamics
@ast
Homology model of the GABAA receptor examined using Brownian dynamics
@en
Homology model of the GABAA receptor examined using Brownian dynamics
@nl
type
label
Homology model of the GABAA receptor examined using Brownian dynamics
@ast
Homology model of the GABAA receptor examined using Brownian dynamics
@en
Homology model of the GABAA receptor examined using Brownian dynamics
@nl
prefLabel
Homology model of the GABAA receptor examined using Brownian dynamics
@ast
Homology model of the GABAA receptor examined using Brownian dynamics
@en
Homology model of the GABAA receptor examined using Brownian dynamics
@nl
P2860
P1433
P1476
Homology model of the GABAA receptor examined using Brownian dynamics
@en
P2093
Michael Parker
Shin-Ho Chung
P2860
P304
P356
10.1529/BIOPHYSJ.104.051664
P407
P577
2005-03-04T00:00:00Z