D-loop formation mediated by PALB2; BRCA2 and RAD51 - Wikidata - awgldk - TriplyDB

D-loop formation mediated by PALB2; BRCA2 and RAD51

D-loop formation mediated by PALB2; BRCA2 and RAD51

http://www.wikidata.org/entity/Q50287365

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Homologous DNA Pairing and Strand Exchange

P527

Q45314242-55412F3A-F90C-4291-B35F-11FBB568C742

P527

D-loop formation mediated by PALB2; BRCA2 and RAD51

http://www.wikidata.org/entity/Q50287365

description

An instance of the biological ...... RCA2 and RAD51 in Homo sapiens

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biologisch proces

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name

D-loop formation mediated by PALB2; BRCA2 and RAD51

@en

type

label

D-loop formation mediated by PALB2; BRCA2 and RAD51

@en

prefLabel

D-loop formation mediated by PALB2; BRCA2 and RAD51

@en

P2860

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P2860

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

Rad51 recombinase and recombination mediators.

Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.

PALB2 links BRCA1 and BRCA2 in the DNA-damage response.

RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination.

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reactome:R-HSA-5693620

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biological process

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Homologous DNA Pairing and Strand Exchange

P3937

R-HSA-5693620

http://www.w3.org/2001/XMLSchema#string

P527

RAD51 associated protein 1

Partner and localizer of BRCA2

3' overhanging ssDNA-DSBs:p-MRN:p-S1981;Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1;DNA2:BLM;WRN:p-S990;Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex

D-Loop:p-MRN:p-S1981;Ac-K3016-ATM:KAT5:EXO1;DNA2:BLM;WRN:p-S990;Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1

P703