p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
about
A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesiclep38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosisThe retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A proteinHighlight: BRCA1 and BRCA2 proteins in breast cancerNegative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP geneArrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcriptionCDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phaseCyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivoFunctional interaction between DP-1 and p53Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-ratThe other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axisTranscriptional control of stem cell fate by E2Fs and pocket proteinsPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Synergistic role of E1A-binding proteins and tissue-specific transcription factors in differentiationRequirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epitheliumFibroblast growth factor receptor signaling is essential for lens fiber cell differentiationThe retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear.Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and developmentCommon and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse modelABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memoryThe tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lensApoptosis: molecular regulation of cell deathRegulation of the cell cycle and apoptosis by the oncogenes of adenovirusMyc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalizationIdentification of differentially expressed genes in mouse Pax6 heterozygous lenses.Retinoblastoma gene promoter directs transgene expression exclusively to the nervous system.Rybp, a polycomb complex-associated protein, is required for mouse eye development.Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo.Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis.Insights into cancer from transgenic mouse models.E2F4 cooperates with pRB in the development of extra-embryonic tissues.Developmental defects and tumor predisposition in Rb mutant mice.Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors.mdm2: a bridge over the two tumour suppressors, p53 and Rb.The retinoblastoma gene family in differentiation and development.Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.Apoptosis in cancer.Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis.Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation.
P2860
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P2860
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh-hant
name
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
@en
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
@nl
type
label
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
@en
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
@nl
prefLabel
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
@en
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
@nl
P2093
P356
P1433
P1476
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.
@en
P2093
DePinho RA
Morgenbesser SD
Williams BO
P2888
P356
10.1038/371072A0
P407
P577
1994-09-01T00:00:00Z
P6179
1026622134