Assessing the distribution of parameters in models of ligand-receptor interaction: to log or not to log.
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Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptorsSynthesis and characterization of a novel tritiated KATP channel opener with a benzopyran structureMultiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheresN-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic propertiesBeyond eyeballing: fitting models to experimental data.From 'captive' agonism to insurmountable antagonism: demonstrating the power of analytical pharmacology.Synchrony of hand-foot coupled movements: is it attained by mutual feedback entrainment or by independent linkage of each limb to a common rhythm generator?Effect of adenosine on membrane potential and Ca2+ in juxtaglomerular cells. Comparison with angiotensin IIMatching models to data: a receptor pharmacologist's guideIdentification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling biasAntagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactionsStructural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.Computer-intensive statistical procedures.Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptorSunscreen penetration of human skin and related keratinocyte toxicity after topical application.Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor.Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimeticsPotent stimulation and inhibition of the CFTR Cl(-) current by phloxine B.A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulationStimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptorProbing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.Towards a structural understanding of allosteric drugs at the human calcium-sensing receptorProposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors.Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors.Use of protein-engineered fabrics to identify design rules for integrin ligand clustering in biomaterials.Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators.Detection and quantification of allosteric modulation of endogenous m4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line.Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.Analysis of two KCNJ11 neonatal diabetes mutations, V59G and V59A, and the analogous KCNJ8 I60G substitution: differences between the channel subtypes formed with SUR1.A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.KATP channel openers of the benzopyran type reach their binding site via the cytosol.Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075.Binding and effect of K ATP channel openers in the absence of Mg2+Mg2+ sensitizes KATP channels to inhibition by DIDS: dependence on the sulphonylurea receptor subunit.The stereoenantiomers of a pinacidil analog open or close cloned ATP-sensitive K+ channels.
P2860
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P2860
Assessing the distribution of parameters in models of ligand-receptor interaction: to log or not to log.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Assessing the distribution of ...... raction: to log or not to log.
@en
Assessing the distribution of ...... raction: to log or not to log.
@nl
type
label
Assessing the distribution of ...... raction: to log or not to log.
@en
Assessing the distribution of ...... raction: to log or not to log.
@nl
prefLabel
Assessing the distribution of ...... raction: to log or not to log.
@en
Assessing the distribution of ...... raction: to log or not to log.
@nl
P1476
Assessing the distribution of ...... raction: to log or not to log.
@en
P2093
Christopoulos A
P304
P356
10.1016/S0165-6147(98)01240-1
P577
1998-09-01T00:00:00Z