Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.
about
Multi-Target Directed Donepezil-Like Ligands for Alzheimer's DiseaseKey Targets for Multi-Target Ligands Designed to Combat NeurodegenerationDual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugsMulti-target drugs: the trend of drug research and developmentNovel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors.Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.The discovery of potential acetylcholinesterase inhibitors: a combination of pharmacophore modeling, virtual screening, and molecular docking studies.Cyclosulfamide-based derivatives as inhibitors of norovirusesStructure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.Design, synthesis and evaluation of genistein-polyamine conjugates as multi-functional anti-Alzheimer agents.Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease.Dual-target-directed drugs that block monoamine oxidase B and adenosine A(2A) receptors for Parkinson's diseaseMulti-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer's Disease.Advantages and limitations of common testing methods for antioxidants.Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors.Design, Synthesis and Evaluation of Novel Tacrine-Ferulic Acid Hybrids as Multifunctional Drug Candidates against Alzheimer's Disease.Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy.Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.Multifunctional iron-chelators with protective roles against neurodegenerative diseases.A novel 7-O-modified genistein derivative with acetylcholinesterase inhibitory effect, estrogenic activity and neuroprotective effect.Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease.Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.(+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations.Synthesis, kinetic studies and molecular modeling of novel tacrine dimers as cholinesterase inhibitors.A sensitive colorimetric strategy for monitoring cerebral β-amyloid peptides in AD based on dual-functionalized gold nanoplasmonic particles.Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.Reactivity of 9-aminoacridine drug quinacrine with glutathione limits its antiprion activity.7-Methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in Alzheimer's disease treatment--synthesis, biological evaluation and molecular modeling studies.Iron exposure modifies acetylcholinesterase activity in zebrafish (Danio rerio) tissues: distinct susceptibility of tissues to iron overload.Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors5-Methyl--(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5-indolo[2,3-]quinolin-11-amine: a highly potent human cholinesterase inhibitorScale Alpha and Beta of Quantitative Convergence and Chemical Reactivity Analysis in Dual Cholinesterase/Monoamine Oxidase Inhibitors for the Alzheimer Disease Treatment Using Density Functional Theory (DFT)
P2860
Q26744105-82D1181C-15E9-470A-8BDD-20BB3917FE51Q28077589-D363C189-67F0-4EAC-95A1-6CC5AFCE7A2FQ28305100-5FD7F1D6-B553-46B3-8FB0-97D2A7D2FE98Q28480888-FFF7B143-8767-425A-ADF5-DD516B3BDD62Q33552783-930B5D5B-6A74-4BA6-B4B8-1E3845F974EAQ33813567-A360F400-1AAF-442C-8BF0-43E9B042C943Q34564278-6E80A066-F392-4C99-9F12-BDC6B300C900Q35675155-EA883D70-A428-47C6-819E-791A579E3140Q36047382-7EFC8E00-FAC8-4636-B347-B97B3373E125Q36237902-998D3767-71D7-4B60-8DA1-CC96A9734200Q36407216-9C8FA715-3FAD-4F79-A774-2C9DF16428CFQ36925910-6A1E7896-7F04-4859-9067-935ED3FC486DQ37358676-85A3FA5A-5A3C-46AE-84EC-C3D10F27EB37Q38213710-0CAD519E-292E-4DB7-BC66-9B2C579917C9Q38289510-4CC3A13E-0F53-4BC1-99E0-2638B8643403Q38720830-3E32C2E2-D638-4151-825D-ADBB5100D01EQ38741686-FB10E654-5DA0-41C7-9C8F-F4CFE2E5CF8CQ38806779-E1C157F1-E5A9-4847-A294-4A0E0A4197C0Q38984017-06D793F4-6BDF-40FE-9C33-99C6434FCE5EQ39181472-EC5BE181-52EA-4AEE-A00A-2ED1A6E22C55Q39261947-0D5B331D-FB47-4855-B799-37530AF829DFQ39459684-67000254-FE50-4E55-81A9-06A0B1F83CB8Q39778610-C04DFFD5-A7BA-4FEA-A56C-1DC97E5C6ADEQ42721755-51DFBEE0-0642-44AB-830A-F427FA736FCCQ43151006-F6FBE712-A7FF-46B8-905C-BCFF39057BC2Q43679582-0F416901-CD49-4DD5-89D7-1A36F6B435CAQ48201744-3F933AC2-8B84-4603-BC95-E83B692A58F4Q48636523-76DAB764-D9B1-4EBC-A339-506A8E43A41BQ51277578-CD13A950-D764-4ECE-AB29-1E78DAD13DE5Q51829717-8F79F6DD-D7D8-4030-9B9E-D15288435385Q53315604-B9C675D0-8840-4C34-9D0C-5EBCDAAEE17AQ56933230-D1AFE036-592C-4ED2-B206-9FFAEA5B060CQ56960330-D84CBE7C-BA37-4C81-ACD9-D6CB03DD65DFQ59022312-5C287F54-35B4-4086-A3B4-656B8235955D
P2860
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Multi-target-directed drug des ...... d against Alzheimer's disease.
@en
Multi-target-directed drug des ...... d against Alzheimer's disease.
@nl
type
label
Multi-target-directed drug des ...... d against Alzheimer's disease.
@en
Multi-target-directed drug des ...... d against Alzheimer's disease.
@nl
prefLabel
Multi-target-directed drug des ...... d against Alzheimer's disease.
@en
Multi-target-directed drug des ...... d against Alzheimer's disease.
@nl
P2093
P50
P356
P1476
Multi-target-directed drug des ...... d against Alzheimer's disease.
@en
P2093
Andrea Cavalli
Carlo Melchiorre
Maria Laura Bolognesi
Maurizio Recanatini
Michela Rosini
P304
P356
10.1021/JM701225U
P407
P577
2007-11-30T00:00:00Z