Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. - Wikidata - awgldk - TriplyDB

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

http://www.wikidata.org/entity/Q53378253

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Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide Numerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic Synapses Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide.Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes.Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples.Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy.Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.The elevated copper binding strength of amyloid-β aggregates allows the sequestration of copper from albumin: a pathway to accumulation of copper in senile plaques Nanoprobing of the effect of Cu(2+) cations on misfolding, interaction and aggregation of amyloid β peptide.Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease.The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease.Revisiting rodent models: Octodon degus as Alzheimer's disease model?Therapeutics for Alzheimer's disease based on the metal hypothesis Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease.Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide.A central role for dityrosine crosslinking of Amyloid-β in Alzheimer's disease.Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease Lens Endogenous Peptide αA66-80 Generates Hydrogen Peroxide and Induces Cell Apoptosis.Capturing a reactive state of amyloid aggregates: NMR-based characterization of copper-bound Alzheimer disease amyloid β-fibrils in a redox cycle.Novel drug targets based on metallobiology of Alzheimer's disease.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity.Aggregation of amyloids in a cellular context: modelling and experiment.Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases.The role of metallobiology and amyloid-β peptides in Alzheimer's disease.Beta-amyloid oligomers: recent developments.Effects of oxidation on redox and cytotoxic properties of copper complex of Aβ1-16 peptide.Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments.Copper inducing Aβ42 rather than Aβ40 nanoscale oligomer formation is the key process for Aβ neurotoxicity.

P2860

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P2860

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

http://www.wikidata.org/entity/Q53378253

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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2006年學術文章

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name

Copper-mediated amyloid-beta t ...... termolecular histidine bridge.

@en

Copper-mediated amyloid-beta t ...... termolecular histidine bridge.

@nl

type

label

Copper-mediated amyloid-beta t ...... termolecular histidine bridge.

@en

Copper-mediated amyloid-beta t ...... termolecular histidine bridge.

@nl

prefLabel

Copper-mediated amyloid-beta t ...... termolecular histidine bridge.

@en

Copper-mediated amyloid-beta t ...... termolecular histidine bridge.

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Copper-mediated amyloid-beta t ...... termolecular histidine bridge.

@en

P2093

Danielle G Smith

http://www.w3.org/2001/XMLSchema#string

Deborah J Tew

http://www.w3.org/2001/XMLSchema#string

Giuseppe D Ciccotosto

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John F Boas

http://www.w3.org/2001/XMLSchema#string

John R Pilbrow

http://www.w3.org/2001/XMLSchema#string

Kevin J Barnham

http://www.w3.org/2001/XMLSchema#string

Keyla Perez

http://www.w3.org/2001/XMLSchema#string

Tong-Lay Lau

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P2860

Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase

Improved preparation of amyloid-beta peptides using DBU as Nalpha-Fmoc deprotection reagent.

Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (A beta 1-40), which may potentially inhibit the fibril formation.

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.

Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.

Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

The channel hypothesis of Alzheimer's disease: current status.

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.

Membrane-disordering effects of beta-amyloid peptides.

P304

15145-15154

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scholarly article

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10.1074/JBC.M600417200

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P433

22

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P478

281

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Colin L. Masters

Frances Šeparović

Cyril C. Curtain

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2006-04-04T00:00:00Z

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P698

16595673

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