B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.
about
Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseasesSiglecs and immune regulationIntracellular nucleic acid sensors and autoimmunityB lymphocyte antigen receptor signaling: initiation, amplification, and regulationAutoantibodies in systemic autoimmune diseases: specificity and pathogenicityB cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esteraseLactation defect in a widely used MMTV-Cre transgenic line of miceFCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signalingMegakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunityB cell receptor signal transduction in the GC is short-circuited by high phosphatase activityT Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells.SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsSiglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activationActivation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell toleranceA balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levelsShp1 signalling is required to establish the long-lived bone marrow plasma cell pool.SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient miceMolecular underpinning of B-cell anergy.SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cellsThe conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms.Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humansDermatan sulfate interacts with dead cells and regulates CD5(+) B-cell fate: implications for a key role in autoimmunityB-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR.Impact of natural IgM concentration on gene therapy with adenovirus type 5 vectors.Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemiaB cells and autoimmunity.Focal exposure of limited lung volumes to high-dose irradiation down-regulated organ development-related functions and up-regulated the immune response in mouse pulmonary tissues.Manipulation of the glycan-specific natural antibody repertoire for immunotherapyB cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens.The steroid and xenobiotic receptor negatively regulates B-1 cell development in the fetal liver.FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival.Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b DegradationTHEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.
P2860
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P2860
B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
B cell-specific deletion of pr ...... causes systemic autoimmunity.
@en
B cell-specific deletion of pr ...... causes systemic autoimmunity.
@nl
type
label
B cell-specific deletion of pr ...... causes systemic autoimmunity.
@en
B cell-specific deletion of pr ...... causes systemic autoimmunity.
@nl
prefLabel
B cell-specific deletion of pr ...... causes systemic autoimmunity.
@en
B cell-specific deletion of pr ...... causes systemic autoimmunity.
@nl
P2093
P1433
P1476
B cell-specific deletion of pr ...... causes systemic autoimmunity.
@en
P2093
Benjamin G Neel
Jeffery L Kutok
Joel M Henderson
Lars Nitschke
Lily I Pao
Marat Alimzhanov
Matthew L Thomas
P356
10.1016/J.IMMUNI.2007.04.016
P407
P577
2007-06-28T00:00:00Z