p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
about
MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7Metabolic control of G1-S transition: cyclin E degradation by p53-induced activation of the ubiquitin-proteasome systemAnalysis and verification of the HMGB1 signaling pathway.Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulationTumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.p53: guardian of ploidyHypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.A sparse Ising model with covariates.Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers.Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.Differences in degradation lead to asynchronous expression of cyclin E1 and cyclin E2 in cancer cells.Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1.Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteinsCyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.Back to the origin: reconsidering replication, transcription, epigenetics, and cell cycle control.Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism.Cellular restriction targeting viral capsids perturbs human immunodeficiency virus type 1 infection of nondividing cells.The PP2A-B56 Phosphatase Opposes Cyclin E Autocatalytic Degradation via Site-Specific DephosphorylationFBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation.Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models.Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis.The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system.Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy.Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer.Cyclin E and FGF8 are downstream cell growth regulators in distinct tumor suppressor effects of ANXA7 in hormone-resistant cancer cells of breast versus prostate originFBXW7: a critical tumor suppressor of human cancers
P2860
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P2860
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
@en
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
@nl
type
label
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
@en
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
@nl
prefLabel
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
@en
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
@nl
P2860
P356
P1433
P1476
p53 and SCFFbw7 cooperatively restrain cyclin E-associated genome instability.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210518
P407
P577
2007-05-07T00:00:00Z