Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells.
about
Priming of protective T cell responses against virus-induced tumors in mice with human immune system componentsThe ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell developmentHumanized mice: novel model for studying mechanisms of human immune-based therapiesLentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populationsMouse models for the study of HCV infection and virus–host interactionsAn Implantable Vascularized Protein Gel Construct That Supports Human Fetal Hepatoblast Survival and Infection by Hepatitis C Virus in MiceA novel mouse model for stable engraftment of a human immune system and human hepatocytesGeneration of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" miceConserved and divergent aspects of human T-cell development and migration in humanized miceReplication of Epstein-Barr virus primary infection in human tonsil tissue explants.Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge.Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells.Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.Novel approaches for immune reconstitution and adaptive immune modeling with human pluripotent stem cells.Human hemato-lymphoid system mice: current use and future potential for medicine.HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice.Highly active antiretroviral therapy potently suppresses HIV infection in humanized Rag2-/-gammac-/- miceHuman NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence.Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.Creation of "humanized" mice to study human immunityHuman thrombopoietin knockin mice efficiently support human hematopoiesis in vivoHuman IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lungDevelopment of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2Rγ(null) humanized mice.Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis.IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo.Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in miceHigh-throughput identification of antigen-specific TCRs by TCR gene capture.Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2rγnull mouse model: a multivariable optimization approachTransgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo.New challenges in modern vaccinologyCorrection of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning.HIV-1 infection and pathogenesis in a novel humanized mouse model.Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infectionHuman immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.Modeling HIV-associated neurocognitive disorders in mice: new approaches in the changing face of HIV neuropathogenesisRNA interference in biology and diseaseCorrection of murine Rag2 severe combined immunodeficiency by lentiviral gene therapy using a codon-optimized RAG2 therapeutic transgene.Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop.
P2860
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P2860
Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Monitoring the effect of gene ...... of p53 in developing T cells.
@en
Monitoring the effect of gene ...... of p53 in developing T cells.
@nl
type
label
Monitoring the effect of gene ...... of p53 in developing T cells.
@en
Monitoring the effect of gene ...... of p53 in developing T cells.
@nl
prefLabel
Monitoring the effect of gene ...... of p53 in developing T cells.
@en
Monitoring the effect of gene ...... of p53 in developing T cells.
@nl
P2093
P1433
P1476
Monitoring the effect of gene ...... of p53 in developing T cells.
@en
P2093
Arie Voordouw
Bianca Blom
Christel H Uittenbogaart
Erwin Wijnands
Hergen Spits
Kees Weijer
Ramon Gimeno
P304
P356
10.1182/BLOOD-2004-02-0656
P407
P577
2004-08-19T00:00:00Z