Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels.
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Gating mechanism of BK (Slo1) channels: so near, yet so farConformational state-dependent anion binding in prestin: evidence for allosteric modulationBK channels: multiple sensors, one activation gateStimulatory action of internal protons on Slo1 BK channelsSteady-state and closed-state inactivation properties of inactivating BK channelsSLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertilityBK potassium channel modulation by leucine-rich repeat-containing proteinsA BK (Slo1) channel journey from molecule to physiology.Coupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site.An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing.Hill coefficients of a polymodal Monod-Wyman-Changeux model for ion channel gating.Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+.Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expressionA charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels.Ion sensing in the RCK1 domain of BK channels.Relative motion of transmembrane segments S0 and S4 during voltage sensor activation in the human BK(Ca) channelModulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1.Setting the stage for molecular dissection of the regulatory components of BK channels.Single-channel kinetics of BK (Slo1) channels.Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.Charge substitution for a deep-pore residue reveals structural dynamics during BK channel gating.A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification.WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling.Patch clamp and perfusion techniques for studying ion channels expressed in Xenopus oocytesThe core domain as the force sensor of the yeast mechanosensitive TRP channel.Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formationAlternatively spliced domains interact to regulate BK potassium channel gating.Allosteric modulation of ion channels: the case of maxi-K.Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels.Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore-quencher pairing.Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channelsEffects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channelsIntra- and intersubunit cooperativity in activation of BK channels by Ca2+A role for the S0 transmembrane segment in voltage-dependent gating of BK channels.Modulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains.Mg2+ enhances voltage sensor/gate coupling in BK channels.Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels.Differential effects of beta 1 and beta 2 subunits on BK channel activity.Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability.
P2860
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P2860
Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Allosteric linkage between voltage and Ca
@nl
Allosteric linkage between vol ...... f BK-type mslo1 K(+) channels.
@en
type
label
Allosteric linkage between voltage and Ca
@nl
Allosteric linkage between vol ...... f BK-type mslo1 K(+) channels.
@en
prefLabel
Allosteric linkage between voltage and Ca
@nl
Allosteric linkage between vol ...... f BK-type mslo1 K(+) channels.
@en
P356
P1433
P1476
Allosteric linkage between vol ...... f BK-type mslo1 K(+) channels.
@en
P2093
P304
15612-15619
P356
10.1021/BI001509+
P407
P577
2000-12-01T00:00:00Z