Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes. - Wikidata - awgldk - TriplyDB

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

http://www.wikidata.org/entity/Q54295290

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A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement Targeting Mitochondria and Reactive Oxygen Species-Driven Pathogenesis in Diabetic Nephropathy Mitochondrial hormesis and diabetic complications Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.Updates of reactive oxygen species in melanoma etiology and progression.New targets for treatment of diabetic nephropathy: what we have learned from animal models.Therapeutic targets for treating fibrotic kidney diseases New insight into the molecular drug target of diabetic nephropathy.Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease.p47(phox) contributes to albuminuria and kidney fibrosis in mice.Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE.NOX2 As a Target for Drug Development: Indications, Possible Complications, and Progress.Role of Nox2 in diabetic kidney disease.NADPH oxidases, reactive oxygen species, and the kidney: friend and foe.Diabetes and Kidney Disease: Role of Oxidative Stress.Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose.Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression.Emerging drugs for managing kidney disease in patients with diabetes.Nox4 and diabetic nephropathy: with a friend like this, who needs enemies?Novel targets of antifibrotic and anti-inflammatory treatment in CKD.Therapeutic approaches to diabetic nephropathy--beyond the RAS.Advances and strategies in NADPH oxidase inhibitors and activators patents.Nox and renal disease.APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.Are reactive oxygen species still the basis for diabetic complications?Diagnosis and treatment of early renal disease in patients with type 2 diabetes mellitus: what are the clinical needs?Hydrogen Sulfide in Renal Physiology and Disease.Therapeutic potential of NADPH oxidase 1/4 inhibitors.Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease.NADPH Oxidase 4 at the Nexus of Diabetes, Reactive Oxygen Species, and Renal Metabolism.Oxidative stress and reactive oxygen species: a review of their role in ocular disease.A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis.Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells.Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways.Aggravation of diabetic nephropathy in BCL-2 interacting cell death suppressor (BIS)-haploinsufficient mice together with impaired induction of superoxide dismutase (SOD) activity.Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms.

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P2860

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

http://www.wikidata.org/entity/Q54295290

description

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2013年学术文章

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2013年學術文章

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2013年學術文章

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name

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

@en

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

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type

label

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

@en

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

@nl

prefLabel

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

@en

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

@nl

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Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.

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Alex Gutsol

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Augusto C Montezano

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Aurelie Nguyen Dinh Cat

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Cedric Szyndralewiez

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Chris R J Kennedy

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Freddy Heitz

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Karin Jandeleit-Dahm

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Kevin D Burns

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Mark E Cooper

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Mona Sedeek

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P2860

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology

Oxidative stress as a major culprit in kidney disease in diabetes

Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling

Subcellular localization of Nox4 and regulation in diabetes

Increased recruitment but impaired function of leukocytes during inflammation in mouse models of type 1 and type 2 diabetes.

End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions.

Mouse models of diabetic nephropathy.

A novel superoxide-producing NAD(P)H oxidase in kidney.

Mesenteric resistance arteries in type 2 diabetic db/db mice undergo outward remodeling.

Association of genetic variants in the promoter region of genes encoding p22phox (CYBA) and glutamate cysteine ligase catalytic subunit (GCLC) and renal disease in patients with type 1 diabetes mellitus.

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124

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type-2 diabetes