about
Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- miceRetinoblastoma family genesPP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.The molecular pathogenesis of pituitary adenomas: an updateContext-dependent requirement for dE2F during oncogenic proliferationDiscovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches.The retinoblastoma tumor-suppressor gene, the exception that proves the ruleTandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions.Construction of a dual affinity tagged allele of the Rb1 tumor suppressor gene in the mouseE2F4 cooperates with pRB in the development of extra-embryonic tissues.Loss of the mammalian DREAM complex deregulates chondrocyte proliferationZebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansionp107 in the public eye: an Rb understudy and more.Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation.Mouse models of endocrine tumours.An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression.Visualizing dynamic E2F-mediated repression in vivo.Clefts, grooves, and (small) pockets: the structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled.The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity.Emerging roles of E2Fs in cancer: an exit from cell cycle controlConstitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues.E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomasConcomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemiaOpposing roles of E2Fs in cell proliferation and death.The RB protein family in retinal development and retinoblastoma: new insights from new mouse models.Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts.Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancerThe RB tumor suppressor positively regulates transcription of the anti-angiogenic protein NOL7Pocket protein function in melanocyte homeostasis and neoplasia.E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpressionRetinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit.RB1, development, and cancer.Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation.Insights from mouse models into human retinoblastomaUpregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition.Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
E2F4 loss suppresses tumorigenesis in Rb mutant mice.
@en
E2F4 loss suppresses tumorigenesis in Rb mutant mice.
@nl
type
label
E2F4 loss suppresses tumorigenesis in Rb mutant mice.
@en
E2F4 loss suppresses tumorigenesis in Rb mutant mice.
@nl
prefLabel
E2F4 loss suppresses tumorigenesis in Rb mutant mice.
@en
E2F4 loss suppresses tumorigenesis in Rb mutant mice.
@nl
P2093
P1433
P1476
E2F4 loss suppresses tumorigenesis in Rb mutant mice
@en
P2093
Brian David Dynlacht
Eunice Y Lee
Jacqueline A Lees
Ulrike Ziebold
P304
P356
10.1016/S1535-6108(02)00207-6
P50
P577
2002-12-01T00:00:00Z