The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7
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Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi networkBursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondinsH3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systemsLgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in miceCrystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targetsFunctional differences of invariant and highly conserved residues in the extracellular domain of the glycoprotein hormone receptorsInvestigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1).Nasal speech and hypothyroidism are common hallmarks of 12q15 microdeletions.New members of the insulin family: regulators of metabolism, growth and now ... reproduction.Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer.Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway.Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathwayRSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications.Lgr5 and Lgr6 as markers to study adult stem cell roles in self-renewal and cancer.Dual blockade of PKA and NF-κB inhibits H2 relaxin-mediated castrate-resistant growth of prostate cancer sublines and induces apoptosis.LGR4 and LGR6 are differentially expressed and of putative tumor biological significance in gastric carcinoma.Identification and developmental expression of leucine-rich repeat-containing G protein-coupled receptor 6 (lgr6) in the medaka fish, Oryzias latipes.Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors.A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.Structural requirements for mutational lutropin/choriogonadotropin receptor activation.R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice.Cloning and expression analysis of follicle-stimulating hormone and luteinizing hormone receptor during the reproductive cycle in Korean rockfish (Sebastes schlegeli).
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The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7
description
im August 2000 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2000
@uk
name
The Three Subfamilies of Leuci ...... e Signaling Mechanism for LGR7
@en
The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors
@nl
type
label
The Three Subfamilies of Leuci ...... e Signaling Mechanism for LGR7
@en
The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors
@nl
prefLabel
The Three Subfamilies of Leuci ...... e Signaling Mechanism for LGR7
@en
The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors
@nl
P356
P1476
The Three Subfamilies of Leuci ...... e Signaling Mechanism for LGR7
@en
P2093
P304
P356
10.1210/ME.14.8.1257
P577
2000-08-01T00:00:00Z