about
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancerA developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNAFBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung developmentInvestigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestinesA basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tractsCo-evolution of X-chromosome inactivation and imprinting in mammals.FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.Genomic imprinting: CTCF protects the boundaries.Chromosome loops, insulators, and histone methylation: new insights into regulation of imprinting in clusters.How imprinting centres work.Five endometrial cancer risk loci identified through genome-wide association analysis.The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencingThe C-terminus of Apc does not influence intestinal adenoma development or progression.Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer.A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region.Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.Epigenetics and imprinting of the trophoblast -- a workshop report.Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions.Erratum to “Epigenetics and Imprinting of the Trophoblast – A Workshop Report” [Placenta 27, supplement A, Trophoblast Research, Vol. 20 S122–S126]
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Annabelle Lewis
@ast
Annabelle Lewis
@en
Annabelle Lewis
@es
Annabelle Lewis
@nl
type
label
Annabelle Lewis
@ast
Annabelle Lewis
@en
Annabelle Lewis
@es
Annabelle Lewis
@nl
prefLabel
Annabelle Lewis
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Annabelle Lewis
@en
Annabelle Lewis
@es
Annabelle Lewis
@nl
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P1153
56392007400
P31
P496
0000-0003-1876-1927