about
A urokinase receptor-associated protein with specific collagen binding propertiesA novel, specific pro-urokinase complex on monocyte-like cells, detected by transglutaminase-catalyzed cross-linkingThe collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review)Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion bindingThe urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodelingM2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasisThe non-phagocytic route of collagen uptake: a distinct degradation pathway.Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesisMT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.The collagen receptor uPARAP/Endo180.The urokinase receptor and regulation of cell surface plasminogen activation.A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP.Complex determinants in specific members of the mannose receptor family govern collagen endocytosisAdvances in targeted delivery of small interfering RNA using simple bioconjugates.Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis.Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells.A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor.Domain interplay in the urokinase receptor. Requirement for the third domain in high affinity ligand binding and demonstration of ligand contact sites in distinct receptor domains.The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers.New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment.Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor.The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation.uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.Localization and functional significance of a polymorphic determinant in the third component of human complement.Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells.Binding of the urokinase-type plasminogen activator to its cell surface receptor is inhibited by low doses of suramin.Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production.Phagocytosis of Collagen Fibrils by Fibroblasts In Vivo Is Independent of the uPARAP/Endo180 Receptor.Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient miceImmune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectinsIncreased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head and Neck CanceruPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesisAntibody-mediated Targeting of the Urokinase-type Plasminogen Activator Proteolytic Function Neutralizes Fibrinolysisin VivoA novel polymorphism of human complement component C3 detected by means of a monoclonal antibody
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Niels Behrendt
@ast
Niels Behrendt
@en
Niels Behrendt
@es
Niels Behrendt
@nl
type
label
Niels Behrendt
@ast
Niels Behrendt
@en
Niels Behrendt
@es
Niels Behrendt
@nl
prefLabel
Niels Behrendt
@ast
Niels Behrendt
@en
Niels Behrendt
@es
Niels Behrendt
@nl
P106
P31
P496
0000-0003-1833-3922