The tumor-suppressive functions of the human INK4A locus
about
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsNuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formationTSPYL5 suppresses p53 levels and function by physical interaction with USP7Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulationInhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated proteinPolycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic ImplicationsGenetic Variants in the p14ARF/MDM2/TP53 Pathway Are Associated with the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated with Radical Resection.Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.shRNA libraries and their use in cancer genetics.Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms.Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivoHistone H3.3 and its proteolytically processed form drive a cellular senescence programmeThe prognostic value of epigenetic silencing of p16 gene in NSCLC patients: a systematic review and meta-analysis.Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.Mutant lamin A links prophase to a p53 independent senescence program.E2F mediates enhanced alternative polyadenylation in proliferation.Noncoding RNAs in cancer medicineTransglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.TLX1/HOX11-mediated disruption of primary thymocyte differentiation prior to the CD4+CD8+ double-positive stage.Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress.BRAF(E600) in benign and malignant human tumours.Loss of VHL promotes progerin expression, leading to impaired p14/ARF function and suppression of p53 activity.Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner.Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts.p53 induces transcriptional and translational programs to suppress cell proliferation and growth.Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts.Distinct E2F-mediated transcriptional program regulates p14ARF gene expression.Retinoblastoma-independent regulation of cell proliferation and senescence by the p53-p21 axis in lamin A /C-depleted cells.BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cellsTelomerase-independent regulation of ATR by human telomerase RNA.Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers.Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.P14ARF deficiency and its correlation with overexpression of p53/MDM2 in sporadic vestibular schwannomas.Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.Germline hemizygous deletion of CDKN2A-CDKN2B locus in a patient presenting with Li-Fraumeni syndrome.
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P2860
The tumor-suppressive functions of the human INK4A locus
description
im Oktober 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 October 2003
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 2003
@uk
name
The tumor-suppressive functions of the human INK4A locus
@en
The tumor-suppressive functions of the human INK4A locus
@nl
type
label
The tumor-suppressive functions of the human INK4A locus
@en
The tumor-suppressive functions of the human INK4A locus
@nl
prefLabel
The tumor-suppressive functions of the human INK4A locus
@en
The tumor-suppressive functions of the human INK4A locus
@nl
P1433
P1476
The tumor-suppressive functions of the human INK4A locus
@en
P2093
P Mathijs Voorhoeve
P304
P356
10.1016/S1535-6108(03)00223-X
P50
P577
2003-10-01T00:00:00Z