Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).
about
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progressionSeveral distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusMel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteinsThe role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-MycThe circadian clock in cancer development and therapyThe proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescenceMYC on the path to cancerSu(z)2 antagonizes auto-repression of Myc in Drosophila, increasing Myc levels and subsequent trans-activationThyroid hormone signaling and adult neurogenesis in mammalsThe relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence.Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.TIMELESS contributes to the progression of breast cancer through activation of MYC.Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue.Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3A theoretical framework for gene induction and experimental comparisons.You Don't Muck with MYCp27Kip1 mediates addiction of ovarian cancer cells to MYCC (c-MYC) and their dependence on MYC paralogs.Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer.Aging, cellular senescence, and cancerMYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms.Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model.Bmi1 drives stem-like properties and is associated with migration, invasion, and poor prognosis in tongue squamous cell carcinoma.What goes on behind closed doors: physiological versus pharmacological steroid hormone actions.Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype.βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.Expression of B-cell-specific Moloney murine leukemia virus integration site 1 mRNA and protein in gastric cancer.Cellular senescence and the aging brain.BMI1 suffers a degrading experience.MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas.Novel ARF/p53-independent senescence pathways in cancer repression.Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivationDeletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethalityEx vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche.FOXA1 mediates p16(INK4a) activation during cellular senescenceTumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradationIRF4 addiction in multiple myelomaGene expression time-series analysis of camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines.Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS.Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence.
P2860
Q24307439-DC876A00-4C14-474A-8498-E2E19FE7B6E8Q24317899-4DDE724F-80CB-4C1E-BCF9-499EE01F8BC7Q24681882-32EBEA02-D259-4144-A088-DA535786272AQ28299585-1F5D7456-A636-4F55-B677-9B0243D789ABQ28390451-3727B180-0FF0-4518-8EAE-288205D36D4AQ28473050-30B45F76-E5ED-4ADE-B65C-6AB7AAA93731Q29619979-A10A2C6C-44C4-4CC2-9F57-971B4E89A81EQ33424513-8AE2B044-546A-4956-B114-F926D4B218C9Q33563767-4104588E-99DE-4E79-B576-7F46B8CAD550Q33588743-EB4823BF-7D98-43DC-B9A7-CAF8F717D977Q33591386-382600CC-2A7A-4240-93A9-8FDB4346352CQ33629724-05A7BBF4-CAD3-4036-9FB0-4071B1942A51Q33708108-E19DFE26-26A2-49DF-B5CD-ECCBDE155536Q33716041-560CCF41-FDC6-4BAD-A6B2-739FC998D0CBQ33859477-4DE94ADB-EAEA-48E6-A33A-C5366F642C1BQ34157211-9346B9B9-057E-4B62-9C00-9B0204F398DEQ34186642-3C65BB86-0764-41C4-8AEF-9846A7490BC8Q34194283-8FD6CE2E-A80B-416A-AB14-556E7A719667Q34199776-6441CB68-3ED3-47AD-82A8-B23C75E0C714Q34248882-96CE2677-766B-4E0F-84A6-7F795641DE87Q34401933-2D40CEF1-B5B4-4022-BB8E-1E0F1FD1BDFBQ34780881-DDE57714-7680-4C5F-A0D0-C4927359D8F7Q34795516-74C8081C-3232-4223-A46A-DA2A0C60D63AQ34958801-2D06599A-6FD5-405A-BBF7-EF873046ABA9Q34988841-30152B34-18DA-4F0A-93F4-DC82A81EDA0BQ35051176-21A0B2D7-0348-4476-B0FD-CDA794E24C88Q35083849-29C2150B-6A5E-4B37-B4F1-FB474B42C06EQ35243675-D92B7264-130D-48C5-B664-FCEC7E01BEFBQ35600306-6CBCEDB7-A49F-4E0D-BEAE-06F2595B91B6Q35609613-21CB188D-45C6-4BF3-9896-D6D681D047E2Q35810716-1C65B33A-C85B-4707-BBFD-516E94BC1A6AQ35928960-754FC190-A6E0-411D-B922-A2E68102D0D8Q36176643-F8BC80E0-93AD-4467-8FF3-BA8FFF188FAAQ36681962-A65EE5B4-33ED-4C83-BB3F-9BFD4B2467CFQ36706114-5CA89C03-A7A6-4A7A-A931-0B1ED01E7D6BQ36832181-268AC2B6-D2AC-4F24-B65A-79A3AC9378CEQ36891060-5A08E67D-6876-40FB-8CF5-F71CCD07CD91Q36916118-DB2B6338-BCF5-4D60-BED6-4CDD1BA4E96EQ37123940-A42FC9A6-4BA8-43D5-AC77-81BA59E7AD65Q37132697-005580A1-A0F6-487D-B740-6FBFB6E80A58
P2860
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Reduced c-Myc signaling trigge ...... ce by regulating Bmi-1 and p16
@nl
Reduced c-Myc signaling trigge ...... gulating Bmi-1 and p16(INK4a).
@ast
Reduced c-Myc signaling trigge ...... gulating Bmi-1 and p16(INK4a).
@en
type
label
Reduced c-Myc signaling trigge ...... ce by regulating Bmi-1 and p16
@nl
Reduced c-Myc signaling trigge ...... gulating Bmi-1 and p16(INK4a).
@ast
Reduced c-Myc signaling trigge ...... gulating Bmi-1 and p16(INK4a).
@en
prefLabel
Reduced c-Myc signaling trigge ...... ce by regulating Bmi-1 and p16
@nl
Reduced c-Myc signaling trigge ...... gulating Bmi-1 and p16(INK4a).
@ast
Reduced c-Myc signaling trigge ...... gulating Bmi-1 and p16(INK4a).
@en
P2093
P2860
P356
P1476
Reduced c-Myc signaling trigge ...... gulating Bmi-1 and p16(INK4a).
@en
P2093
Isil Guney
John M Sedivy
Shirley Wu
P2860
P304
P356
10.1073/PNAS.0600069103
P407
P577
2006-02-28T00:00:00Z