about
Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus.Emerging Molecular and Biological Functions of MBD2, a Reader of DNA MethylationThe role of epigenetic inactivation of 14-3-3sigma in human cancerComponents of the DNA methylation system of chromatin control are RNA-binding proteinsDeficiency of Mbd2 attenuates Wnt signalingProstate cancer is characterized by epigenetic silencing of 14-3-3sigma expression.The methyl-CpG binding proteins Mecp2, Mbd2 and Kaiso are dispensable for mouse embryogenesis, but play a redundant function in neural differentiation.Smek promotes corticogenesis through regulating Mbd3's stability and Mbd3/NuRD complex recruitment to genes associated with neurogenesisMethyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.Cancer biology and NuRD: a multifaceted chromatin remodelling complexWnt signaling in cancerSynergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasivenessMouse models of gastrointestinal tumors.Genomic insights into cancer-associated aberrant CpG island hypermethylationMethylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell lineTime-Resolved Fluorescence Resonance Energy Transfer Assay for Discovery of Small-Molecule Inhibitors of Methyl-CpG Binding Domain Protein 2.Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cellsMBD2 is required for correct spatial gene expression in the gut.Epigenetic silencing of serine protease HTRA1 drives polyploidy.Reading the DNA methylation signal.Epigenetics provides a new generation of oncogenes and tumour-suppressor genes.Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylation.DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases.Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Wnt signaling and gastrointestinal tumorigenesis in mouse models.The nucleosome remodeling and deacetylase complex in development and disease.Genetic and epigenetic analyses of MBD3 in colon and lung cancer.Proteins that bind methylated DNA and human cancer: reading the wrong words.Cancer genetics of epigenetic genes.Tagging methyl-CpG-binding domain proteins reveals different spatiotemporal expression and supports distinct functions.Epigenetic regulation of mammalian stem cellsMbd2 promotes foxp3 demethylation and T-regulatory-cell function.DNA methylation and methyl-CpG binding proteins: developmental requirements and function.Epigenetic alterations in human prostate cancers.The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genesAPC and its modifiers in colon cancer.The Roles of the Methyl-CpG Binding Proteins in Cancer.
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P2860
description
im Mai 2003 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в травні 2003
@uk
name
Deficiency of Mbd2 suppresses intestinal tumorigenesis
@en
Deficiency of Mbd2 suppresses intestinal tumorigenesis
@nl
type
label
Deficiency of Mbd2 suppresses intestinal tumorigenesis
@en
Deficiency of Mbd2 suppresses intestinal tumorigenesis
@nl
prefLabel
Deficiency of Mbd2 suppresses intestinal tumorigenesis
@en
Deficiency of Mbd2 suppresses intestinal tumorigenesis
@nl
P2093
P50
P356
P1433
P1476
Deficiency of Mbd2 suppresses intestinal tumorigenesis
@en
P2093
Adrian Bird
Jennifer Berger
Stefan M Bishop
P2888
P304
P356
10.1038/NG1155
P407
P577
2003-05-05T00:00:00Z