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HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACKUSP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly.UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathwayThe E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interactionThe E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinaseSCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathwayCalcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibitionBiogenesis and function of multivesicular bodiesRoles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cellsThe life cycle of the 26S proteasome: from birth, through regulation and function, and onto its deathNEDD4: a promising target for cancer therapyRegulation of clathrin-mediated endocytosis by dynamic ubiquitination and deubiquitination.A mechanism for protein monoubiquitination dependent on a trans-acting ubiquitin-binding domain.Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination systemA small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent mannerZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylationA SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomesUSP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.The ubiquitination code: a signalling problem.The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognitionAnimal HECT ubiquitin ligases: evolution and functional implications.Armadillo Repeat Containing 8alpha Binds to HRS and Promotes HRS Interaction with Ubiquitinated Proteins.The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndromeThe ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylationSignaling-mediated control of ubiquitin ligases in endocytosis.When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.Intracellular ubiquitylation of the epithelial Na+ channel controls extracellular proteolytic channel activation via conformational change.Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis.The many faces of ubiquitinated histone H2A: insights from the DUBs.Proteomic snapshot of the EGF-induced ubiquitin networkWerner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.Versatile roles of k63-linked ubiquitin chains in trafficking.gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway.Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damageA single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitinationMono-ubiquitination drives nuclear export of the human DCN1-like protein hDCNL1A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sorting
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description
im Oktober 2006 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 2006
@uk
name
Molecular mechanisms of coupled monoubiquitination
@en
Molecular mechanisms of coupled monoubiquitination
@nl
type
label
Molecular mechanisms of coupled monoubiquitination
@en
Molecular mechanisms of coupled monoubiquitination
@nl
prefLabel
Molecular mechanisms of coupled monoubiquitination
@en
Molecular mechanisms of coupled monoubiquitination
@nl
P2093
P2860
P356
P1433
P1476
Molecular mechanisms of coupled monoubiquitination
@en
P2093
Barbara Oldrini
Elena Cavallaro
Elena Maspero
Pier Paolo Di Fiore
Simona Polo
Tanja Woelk
P2860
P2888
P304
P356
10.1038/NCB1484
P577
2006-10-01T00:00:00Z
P6179
1040801938