Divalent Cations Differentially Regulate Integrin αIIbCytoplasmic Tail Binding to β3and to Calcium- and Integrin-binding Protein
about
Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulationOligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domainsThe small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreadingInvolvement of transmembrane domain interactions in signal transduction by alpha/beta integrinsA structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunitSolution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunitsNMR solution conformations and interactions of integrin alphaLbeta2 cytoplasmic tailsStructures and Interaction Analyses of Integrin M 2 Cytoplasmic TailsAncient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domainIntegrin β3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switchTransmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.Transmembrane and Juxtamembrane Structure of αL Integrin in Bicelles.CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation.Integrin activation by talin.Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in plateletsTransmembrane signal transduction of the alpha(IIb)beta(3) integrin.Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption. Identification of cardiotoxins as non-RGD integrin-binding proteins of the Ly-6 family.Calcium integrin-binding protein activates platelet integrin alpha IIbbeta 3.A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation.Calreticulin-independent regulation of the platelet integrin alphaIIbbeta3 by the KVGFFKR alphaIIb-cytoplasmic motif.Ancient ubiquitous protein 1 and Syk link cytoplasmic tails of the integrin alpha(IIb)beta(3).Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.The MIG-2/integrin interaction strengthens cell-matrix adhesion and modulates cell motility.
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P2860
Divalent Cations Differentially Regulate Integrin αIIbCytoplasmic Tail Binding to β3and to Calcium- and Integrin-binding Protein
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Juni 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в червні 1999
@uk
name
Divalent Cations Differentiall ...... - and Integrin-binding Protein
@en
Divalent Cations Differentiall ...... - and Integrin-binding Protein
@nl
type
label
Divalent Cations Differentiall ...... - and Integrin-binding Protein
@en
Divalent Cations Differentiall ...... - and Integrin-binding Protein
@nl
prefLabel
Divalent Cations Differentiall ...... - and Integrin-binding Protein
@en
Divalent Cations Differentiall ...... - and Integrin-binding Protein
@nl
P2093
P2860
P356
P1476
Divalent cations differentiall ...... - and integrin-binding protein
@en
P2093
P2860
P304
17257-17266
P356
10.1074/JBC.274.24.17257
P407
P577
1999-06-01T00:00:00Z