Association of Frabin with the Actin Cytoskeleton Is Essential for Microspike Formation through Activation of Cdc42 Small G Protein
about
The Traf2- and Nck-interacting kinase as a putative effector of Rap2 to regulate actin cytoskeletonMitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinaseRap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowthCooperation of Cdc42 small G protein-activating and actin filament-binding activities of frabin in microspike formationRhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development.Involvement of Cdc42 and Rac small G proteins in invadopodia formation of RPMI7951 cells.Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10).Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cellsLoss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice.Frabin and other related Cdc42-specific guanine nucleotide exchange factors couple the actin cytoskeleton with the plasma membraneMinireview: Role of genetic changes of faciogenital dysplasia protein 1 in human disease.A novel mutation in FGD4/FRABIN causes Charcot Marie Tooth disease type 4H in patients from a consanguineous Tunisian family.Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.RA-RhoGAP, Rap-activated Rho GTPase-activating protein implicated in neurite outgrowth through Rho.Association of frabin with specific actin and membrane structures.Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac.Importance of spatial activation of Cdc42 and rac small G proteins by frabin for microspike formation in MDCK cells.Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG.Regulation of cell separation in the dimorphic fungus Ustilago maydis.Inverted formin 2-related Charcot-Marie-Tooth disease: extension of the mutational spectrum and pathological findings in Schwann cells and axons.Two novel missense mutations in FGD4/FRABIN cause Charcot-Marie-Tooth type 4H (CMT4H).
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P2860
Association of Frabin with the Actin Cytoskeleton Is Essential for Microspike Formation through Activation of Cdc42 Small G Protein
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im September 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 1999
@uk
name
Association of Frabin with the ...... ation of Cdc42 Small G Protein
@en
Association of Frabin with the ...... ation of Cdc42 Small G Protein
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type
label
Association of Frabin with the ...... ation of Cdc42 Small G Protein
@en
Association of Frabin with the ...... ation of Cdc42 Small G Protein
@nl
prefLabel
Association of Frabin with the ...... ation of Cdc42 Small G Protein
@en
Association of Frabin with the ...... ation of Cdc42 Small G Protein
@nl
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P1476
Association of frabin with the ...... ation of Cdc42 small G protein
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P2093
K Satoh-Horikawa
K Takahashi
Y Matsuura
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P304
25197-25200
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10.1074/JBC.274.36.25197
P407
P577
1999-09-01T00:00:00Z