about
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive targetAPE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survivalNovel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.Targeting DNA repair pathways for cancer treatment: what's new?Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Tissue Transglutaminase Activates Cancer-Associated Fibroblasts and Contributes to Gemcitabine Resistance in Pancreatic Cancer.Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growthDNA repair in neurons: so if they don't divide what's to repair?STAT3 in the systemic inflammation of cancer cachexia.Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer TherapeuticsRole of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions.Embryonic stem cells lacking the epigenetic regulator Cfp1 are hypersensitive to DNA-damaging agents and exhibit decreased Ape1/Ref-1 protein expression and endonuclease activity.Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells.Loss of MTSS1 results in increased metastatic potential in pancreatic cancer.Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers.Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.Role of GADD34 in modulation of cisplatin cytotoxicity.Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition.Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular NeovascularizationDevelopment of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug ScreeningBlocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survivalIdentification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic CancerLTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data
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description
researcher ORCID ID = 0000-0002-9436-6382
@en
name
Melissa Fishel
@ast
Melissa Fishel
@en
Melissa Fishel
@es
Melissa Fishel
@nl
type
label
Melissa Fishel
@ast
Melissa Fishel
@en
Melissa Fishel
@es
Melissa Fishel
@nl
prefLabel
Melissa Fishel
@ast
Melissa Fishel
@en
Melissa Fishel
@es
Melissa Fishel
@nl
P1153
6602556727
P31
P496
0000-0002-9436-6382