Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1
about
Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1Redox-directed cancer therapeutics: molecular mechanisms and opportunitiesCancer drug resistance: redox resetting renders a wayHuman AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis riskHydrogen peroxide sensing, signaling and regulation of transcription factorsA genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survivalThe Anti-Apoptotic Properties of APEX1 in the Endothelium Require the First 20 Amino Acids and Converge on Thioredoxin-1.Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium.Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein.The many functions of APE1/Ref-1: not only a DNA repair enzymeIdentification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor.Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1).Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functionsApurinic/apyrimidinic endonuclease/redox effector factor-1(APE/Ref-1): a unique target for the prevention and treatment of human melanoma.Small molecule inhibitors of DNA repair nuclease activities of APE1.Targeting DNA repair proteins for cancer treatmentIdentification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitorsInhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis.Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo.Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1.Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1.Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro.Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme.Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growthKnock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and functionApurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages.Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neuronsEndothelial cell tumor growth is Ape/ref-1 dependentAn APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypesSecreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor.Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression.
P2860
Q24303442-7F331C1E-4D0F-4FDD-9B6E-C8893ACA6D0CQ24645584-ED29D618-440A-4D35-8495-0B0AFEAA6606Q26750753-9A545B7D-B19A-48B1-80FE-2EBC40A93550Q26863138-E82FB235-D950-4965-A09A-36368CFEA172Q27004438-2FCD4508-B7ED-4ADF-BBF9-08FC45366296Q28387660-A2563C46-5AE8-4A9A-95D4-2123C6ACC37AQ28484500-261D33E2-B1FA-4D9C-AAB8-95B840FA70F7Q30275431-204EF0F6-6E2C-4F5B-81E0-1483B186A2DEQ30429874-87C98809-8643-4B12-AA2E-FA131A4E4E8CQ30434808-9F66B87D-3A9B-4FF5-ACB9-187D620EFED4Q33609187-5E1398EB-231E-431D-8094-74B3F7D61D6DQ33632423-1F486D4E-D567-4302-BFD9-7C3D794E422EQ33709696-1A0FDB59-96A9-4BF8-89AA-2CC25B72944DQ33830130-AC1A7A2A-EC79-4696-8D42-358BB4D4B3AFQ33930876-C2F2D78D-D3DB-42F0-9CC0-FF6423658D4FQ33990581-DF27143B-D716-4010-A7BC-DDC801971392Q34104950-DDD8B780-AABD-471A-8124-6BA195AC9BCAQ34208966-2C539624-E2A1-4721-A179-C12A7006993CQ34208979-663D0389-E108-416F-B1EF-E9D7F8B6C3A5Q34334481-C8266EF4-AC7D-4D49-BA59-D49153FF8A83Q34389148-3C352F3F-4C0C-4E7A-A9D6-5573F8F19DC0Q34441618-8FF6A31F-F8E5-45B6-8ECD-9F962C57882AQ34470985-19C9B947-DE8C-4A52-B384-13F6B2110341Q34700214-8EF9BDF3-7748-4E8C-8012-D0C4782A08A4Q34708764-A1411960-1F19-4F1C-A5D2-536939F7007EQ34758053-25DD56CF-7339-4E66-A6DB-F6F3E3006085Q35048909-6341F981-0625-4FBA-9DDA-267A47C01B46Q35119433-2EF6E8F3-E1EF-48A6-96EA-025D9E71764EQ35206699-85E8EA2E-EA71-4D6D-8FE7-5B6122595F7BQ35340740-0110073C-A91E-41C5-8D53-1A959180DDC4Q35667918-1BEC0EAE-9E9C-44D1-9F66-85E2A4C0A551Q35800938-DCB1EA86-6656-4342-ABFC-3EE19E938E70Q35870045-C552F307-8C48-4EA8-B63D-4B152B06E05AQ35989948-3B8212FC-58F4-45F9-82EF-E2264B8E1BFAQ36017630-8CF084EF-AA5C-443A-B98F-75DD39955548Q36336086-EF9F27D0-DEFB-4FF7-9735-FCA5D614A255Q36675119-53F48D2E-CE0A-4221-9F47-FDFED0819A73Q36996445-AC9AC3CB-DE73-47B8-82B9-11EC817E4123Q37242539-0D5DAFDB-27AB-417B-BEDF-13DC4255B917Q37332450-60DDB2CE-0EEE-40C4-B324-02C0F641ACFA
P2860
Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Role of the multifunctional DN ...... of the redox function of Ape1
@en
type
label
Role of the multifunctional DN ...... of the redox function of Ape1
@en
prefLabel
Role of the multifunctional DN ...... of the redox function of Ape1
@en
P2093
P2860
P356
P1476
Role of the multifunctional DN ...... of the redox function of Ape1
@en
P2093
Aihua Jiang
April Reed
Mark R Kelley
Meihua Luo
Richard F Borch
Rodney L Nyland
Sarah Delaplane
Xiaoxi Qiao
P2860
P304
P356
10.1089/ARS.2008.2120
P577
2008-11-01T00:00:00Z